tert-butyl {(1S)-1-cyclohexyl-2-[(3S,8aS)-3-[(4R)-3,4-dihydro-2H-chromene-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazine-2(1H)-yl]-2-oxoethyl}carbamate

Base Information

Chemical Name:tert-butyl {(1S)-1-cyclohexyl-2-[(3S,8aS)-3-[(4R)-3,4-dihydro-2H-chromene-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazine-2(1H)-yl]-2-oxoethyl}carbamate
CAS No.:1266230-88-9
Molecular Formula:C₃₀H₄₄N₄O₅
Molecular Weight:540.703
Hs Code.:

Synonyms:tert-butyl {(1S)-1-cyclohexyl-2-[(3S,8aS)-3-[(4R)-3,4-dihydro-2H-chromene-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazine-2(1H)-yl]-2-oxoethyl}carbamate

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Chemical Property of tert-butyl {(1S)-1-cyclohexyl-2-[(3S,8aS)-3-[(4R)-3,4-dihydro-2H-chromene-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazine-2(1H)-yl]-2-oxoethyl}carbamate

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Technology Process of tert-butyl {(1S)-1-cyclohexyl-2-[(3S,8aS)-3-[(4R)-3,4-dihydro-2H-chromene-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazine-2(1H)-yl]-2-oxoethyl}carbamate

There total 2 articles about tert-butyl {(1S)-1-cyclohexyl-2-[(3S,8aS)-3-[(4R)-3,4-dihydro-2H-chromene-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazine-2(1H)-yl]-2-oxoethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S,8aS)-N-[(4R)-3,4-dihydro-2H-chromene-4-yl]octahydropyrrolo[1,2-a]pyrazine-3-carboxamide dihydrochloride

: 109183-71-3
N-(tert-butoxycarbonyl)-L-cyclohexylglycine

: 1266230-88-9
tert-butyl {(1S)-1-cyclohexyl-2-[(3S,8aS)-3-[(4R)-3,4-dihydro-2H-chromene-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazine-2(1H)-yl]-2-oxoethyl}carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1266229-51-9
tert-butyl (3S,8aS)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

: 1266230-88-9
tert-butyl {(1S)-1-cyclohexyl-2-[(3S,8aS)-3-[(4R)-3,4-dihydro-2H-chromene-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazine-2(1H)-yl]-2-oxoethyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.09.067