4-((2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-hydroxy-oxepan-2-yl)-butan-2-one

Base Information

Chemical Name:4-((2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-hydroxy-oxepan-2-yl)-butan-2-one
CAS No.:924656-67-7
Molecular Formula:C₂₅H₃₂O₅
Molecular Weight:412.526
Hs Code.:

Synonyms:4-((2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-hydroxy-oxepan-2-yl)-butan-2-one

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Chemical Property of 4-((2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-hydroxy-oxepan-2-yl)-butan-2-one

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Technology Process of 4-((2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-hydroxy-oxepan-2-yl)-butan-2-one

There total 7 articles about 4-((2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-hydroxy-oxepan-2-yl)-butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 924656-37-1
4-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-oxepan-2-yl]-butan-2-one

: 924656-67-7
4-((2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-hydroxy-oxepan-2-yl)-butan-2-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2.5h;
DOI:10.1021/ja066772y

Reference yield:

: (2R,4aR,6S,7R,9aS)-7-Benzyloxy-6-benzyloxymethyl-2-phenyl-hexahydro-1,3,5-trioxa-benzocycloheptene

: 924656-67-7
4-((2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-hydroxy-oxepan-2-yl)-butan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 9.10 g / CSA / methanol; CHCl₃ / 20 °C

2.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

2.2: CH₂Cl₂ / 0.75 h / -78 - 20 °C

3.1: 272.1 mg / CuBr / diethyl ether / 1 h / 0 °C

4.1: 92 percent / PdCl₂; O₂; Cu(OAc)2 / H₂O; N,N-dimethyl-acetamide / 36 h / 20 °C

5.1: TBAF / tetrahydrofuran / 2.5 h / 20 °C

With 2,6-dimethylpyridine; copper diacetate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; oxygen; copper(I) bromide; palladium dichloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; N,N-dimethyl acetamide; water; 4.1: Wacker-Tsuji reaction;
DOI:10.1021/ja066772y

Reference yield:

: 850656-74-5
((2R,4aR,6S,7R,9aS)-7-Benzyloxy-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-yl)-methanol

: 924656-67-7
4-((2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-hydroxy-oxepan-2-yl)-butan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C

1.2: tetrahydrofuran; dimethylformamide / 1 h / 20 °C

2.1: 9.10 g / CSA / methanol; CHCl₃ / 20 °C

3.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

3.2: CH₂Cl₂ / 0.75 h / -78 - 20 °C

4.1: 272.1 mg / CuBr / diethyl ether / 1 h / 0 °C

5.1: 92 percent / PdCl₂; O₂; Cu(OAc)2 / H₂O; N,N-dimethyl-acetamide / 36 h / 20 °C

6.1: TBAF / tetrahydrofuran / 2.5 h / 20 °C

With 2,6-dimethylpyridine; copper diacetate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; oxygen; sodium hydride; copper(I) bromide; palladium dichloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 5.1: Wacker-Tsuji reaction;
DOI:10.1021/ja066772y