Technology Process of (3-Chloro-phenyl)-isoquinolin-1-yl-methanol; hydrochloride
There total 4 articles about (3-Chloro-phenyl)-isoquinolin-1-yl-methanol; hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; potassium hydroxide;
In
ethanol; dichloromethane;
for 1h;
ultrasound sonication;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 69 percent / triethylbenzylammonmium chloride / CH2Cl2; H2O / 0.33 h / Irradiation; ultrasound sonication
2: 100 percent / 50percent aq. NaOH / triethylbenzylammonium chloride / acetonitrile / 0.08 h / ultrasound sonication
3: 99 percent / 1.) 3 N KOH; 2.) HCl(g) / ethanol; CH2Cl2 / 1 h / ultrasound sonication
With
hydrogenchloride; potassium hydroxide; sodium hydroxide;
N-benzyl-N,N,N-triethylammonium chloride;
In
ethanol; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / 50percent aq. NaOH / triethylbenzylammonium chloride / acetonitrile / 0.08 h / ultrasound sonication
2: 99 percent / 1.) 3 N KOH; 2.) HCl(g) / ethanol; CH2Cl2 / 1 h / ultrasound sonication
With
hydrogenchloride; potassium hydroxide; sodium hydroxide;
N-benzyl-N,N,N-triethylammonium chloride;
In
ethanol; dichloromethane; acetonitrile;