ethyl 5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-4-carboxylate

Base Information

• Chemical Name: ethyl 5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-4-carboxylate
• CAS No.: 1138412-57-3
• Molecular Formula: C₃₁H₃₄N₂O₆
• Molecular Weight: 530.621

Synonyms:ethyl 5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-4-carboxylate

Chemical Property of ethyl 5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-4-carboxylate

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Technology Process of ethyl 5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-4-carboxylate

There total 2 articles about ethyl 5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl (4S*,5S*)-5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-6-hydroxy-3-(4-methoxyphenyl)-2-oxohexahydropyrimidine-4-carboxylate → ethyl 5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-4-carboxylate (1138412-57-3)

Guidance literature:

With trifluoroacetic acid; In 1,4-dioxane; water; at 20 ℃; for 24h;

DOI:10.1021/ol900173t

Reference yield: 38.0%

(2S*,3S*)-ethyl 3-benzyl-2-(4-methoxyphenylamino)-4-oxobutanoate + 3,4-dimethoxyphenethyl isocyanate (35167-81-8) → ethyl 5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-4-carboxylate (1138412-57-3) + ethyl (4S*,5S*)-5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-6-hydroxy-3-(4-methoxyphenyl)-2-oxohexahydropyrimidine-4-carboxylate + ethyl (4S*,5S*)-5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-6-hydroxy-3-(4-methoxyphenyl)-2-oxohexahydropyrimidine-4-carboxylate

Guidance literature:

(2S*,3S*)-ethyl 3-benzyl-2-(4-methoxyphenylamino)-4-oxobutanoate; 3,4-dimethoxyphenethyl isocyanate; In dichloromethane; at 60 ℃; for 48h;

With trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; at 20 ℃; for 4h;

DOI:10.1021/ol900173t

Reference yield: 67.0%

ethyl 5-benzyl-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-4-carboxylate (1138412-57-3) → ethyl (1R*,2S*,11bS*)-1-benzyl-9,10-dimethoxy-3-(4-methoxyphenyl)-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrimido[6,1-a]isoquinoline-2-carboxylate

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol900173t

upstream raw materials:

3,4-dimethoxyphenethyl isocyanate

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