ethyl 4-(4-(2-amino-8-methoxy-5,6-dihydrobenzo[h]quinazolin-4-yl)phenoxy)butanoate

Base Information

• Chemical Name: ethyl 4-(4-(2-amino-8-methoxy-5,6-dihydrobenzo[h]quinazolin-4-yl)phenoxy)butanoate
• CAS No.: 1469863-72-6
• Molecular Formula: C₂₅H₂₇N₃O₄
• Molecular Weight: 433.507

Synonyms:ethyl 4-(4-(2-amino-8-methoxy-5,6-dihydrobenzo[h]quinazolin-4-yl)phenoxy)butanoate

Chemical Property of ethyl 4-(4-(2-amino-8-methoxy-5,6-dihydrobenzo[h]quinazolin-4-yl)phenoxy)butanoate

Chemical Property:

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Technology Process of ethyl 4-(4-(2-amino-8-methoxy-5,6-dihydrobenzo[h]quinazolin-4-yl)phenoxy)butanoate

There total 4 articles about ethyl 4-(4-(2-amino-8-methoxy-5,6-dihydrobenzo[h]quinazolin-4-yl)phenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Ethyl 4-bromobutyrate (2969-81-5) + 8-methoxy-4-(4-hydroxyphenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine (1469863-67-9) → ethyl 4-(4-(2-amino-8-methoxy-5,6-dihydrobenzo[h]quinazolin-4-yl)phenoxy)butanoate (1469863-72-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

DOI:10.1016/j.bmcl.2013.08.101

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → ethyl 4-(4-(2-amino-8-methoxy-5,6-dihydrobenzo[h]quinazolin-4-yl)phenoxy)butanoate (1469863-72-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / 1,4-dioxane / 0.17 h / 20 °C

1.2: 72 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 36.5 h / 0 - 120 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

With boron trifluoride diethyl etherate; sodium hydride; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.08.101

Reference yield:

6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → ethyl 4-(4-(2-amino-8-methoxy-5,6-dihydrobenzo[h]quinazolin-4-yl)phenoxy)butanoate (1469863-72-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / 1,4-dioxane / 0.17 h / 20 °C

1.2: 72 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 36.5 h / 0 - 120 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

With boron trifluoride diethyl etherate; sodium hydride; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.08.101

upstream raw materials:

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Ethyl 4-bromobutyrate

8-methoxy-4-(4-hydroxyphenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

4-hydroxy-benzaldehyde

Downstream raw materials:

C₂₃H₂₅N₅O₃

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