6-tert-butyl-4-oxo-1-pentyl-N₃-(phenyl)-1,4-dihydropyridine-3-carboxamide

Base Information

Chemical Name:6-tert-butyl-4-oxo-1-pentyl-N₃-(phenyl)-1,4-dihydropyridine-3-carboxamide
CAS No.:1403498-92-9
Molecular Formula:C₂₁H₂₈N₂O₂
Molecular Weight:340.466
Hs Code.:

6-tert-butyl-4-oxo-1-pentyl-N<sub>3</sub>-(phenyl)-1,4-dihydropyridine-3-carboxamide

Synonyms:6-tert-butyl-4-oxo-1-pentyl-N₃-(phenyl)-1,4-dihydropyridine-3-carboxamide

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Chemical Property of 6-tert-butyl-4-oxo-1-pentyl-N₃-(phenyl)-1,4-dihydropyridine-3-carboxamide

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Technology Process of 6-tert-butyl-4-oxo-1-pentyl-N₃-(phenyl)-1,4-dihydropyridine-3-carboxamide

There total 6 articles about 6-tert-butyl-4-oxo-1-pentyl-N₃-(phenyl)-1,4-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1256382-47-4
6-(tert-butyl)-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxylic acid

: 62-53-3
aniline

: 1403498-92-9
6-tert-butyl-4-oxo-1-pentyl-N₃-(phenyl)-1,4-dihydropyridine-3-carboxamide

Guidance literature:: 6-(tert-butyl)-4-oxo-1-pentyl-1,4-dihydropyridine-3-carboxylic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

aniline; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm3008568

Reference yield:

: 134653-81-9
ethyl 6-tert-butyl-4-oxo-4H-pyran-3-carboxylate

: 1403498-92-9
6-tert-butyl-4-oxo-1-pentyl-N₃-(phenyl)-1,4-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / ethanol / 4 h / Reflux

2.1: sodium hydroxide / ethanol / 6 h / Reflux

3.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3.2: 16 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1021/jm3008568

Reference yield:

: 134653-70-6,51145-57-4
ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

: 1403498-92-9
6-tert-butyl-4-oxo-1-pentyl-N₃-(phenyl)-1,4-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

1.2: 0.75 h / 20 °C

2.1: acetic acid / ethanol / 4 h / Reflux

3.1: sodium hydroxide / ethanol / 6 h / Reflux

4.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4.2: 16 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm3008568