((R)-1-phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylamine

Base Information

Chemical Name:((R)-1-phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylamine
CAS No.:405892-95-7
Molecular Formula:C₁₉H₂₀N₂O
Molecular Weight:292.381
Hs Code.:

Synonyms:((R)-1-phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylamine

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Chemical Property of ((R)-1-phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylamine

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Technology Process of ((R)-1-phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylamine

There total 11 articles about ((R)-1-phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

: 2,2,2-trifluoro-N-((R)-1-phenylethyl)-N-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylacetamide

: 405892-95-7
((R)-1-phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylamine

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 17h;

Reference yield:

: 2380-94-1
1H-indol-4-ol

: 405892-95-7
((R)-1-phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylamine

Guidance literature:: Multi-step reaction with 10 steps

1.1: trichlorophosphate / 2 h / 20 °C

1.2: 0.25 h

2.1: dmap / acetonitrile / 3 h / 0 °C

3.1: sodium hydride / tetrahydrofuran / 19 h / 0 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 1 h

4.2: 3 h / 50 °C

5.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

5.2: 4 h / 0 °C

6.1: 1,4-dioxane / 0.33 h / Heating / reflux

7.1: hydrogenchloride / 1,4-dioxane; water / 0.33 h / Heating / reflux

8.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 18 h / 20 °C

9.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

10.1: sodium tetrahydroborate / ethanol / 17 h / 20 °C

With hydrogenchloride; dmap; sodium hydroxide; sodium tetrahydroborate; chloroformic acid ethyl ester; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;

Reference yield:

: 81779-27-3
4-Hydroxyindole-3-carbaldehyde

: 405892-95-7
((R)-1-phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylamine

Guidance literature:: Multi-step reaction with 10 steps

1.1: dmap / acetonitrile / 3 h / 0 °C

2.1: 1,4-diaza-bicyclo[2.2.2]octane / 24 h / 4 °C

3.1: pyridine; acetic anhydride / 1 h / 0 °C

3.2: 6 h / 80 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 1 h

4.2: 3 h / 50 °C

5.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

5.2: 4 h / 0 °C

6.1: 1,4-dioxane / 0.33 h / Heating / reflux

7.1: hydrogenchloride / 1,4-dioxane; water / 0.33 h / Heating / reflux

8.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 18 h / 20 °C

9.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

10.1: sodium tetrahydroborate / ethanol / 17 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; dmap; sodium hydroxide; sodium tetrahydroborate; chloroformic acid ethyl ester; acetic anhydride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;