1-(3-chlorophenyl)-N-1-{6-[8-(2-morpholin-4-ylethylamino)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}propane-1,3-diamine hydrochloride

Base Information

Chemical Name:1-(3-chlorophenyl)-N-1-{6-[8-(2-morpholin-4-ylethylamino)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}propane-1,3-diamine hydrochloride
CAS No.:1400670-18-9
Molecular Formula:C₂₆H₃₁ClN₈O*ClH
Molecular Weight:543.499
Hs Code.:

Synonyms:1-(3-chlorophenyl)-N-1-{6-[8-(2-morpholin-4-ylethylamino)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}propane-1,3-diamine hydrochloride

Suppliers and Price of 1-(3-chlorophenyl)-N-1-{6-[8-(2-morpholin-4-ylethylamino)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}propane-1,3-diamine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3-chlorophenyl)-N-1-{6-[8-(2-morpholin-4-ylethylamino)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}propane-1,3-diamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3-chlorophenyl)-N-1-{6-[8-(2-morpholin-4-ylethylamino)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}propane-1,3-diamine hydrochloride

There total 11 articles about 1-(3-chlorophenyl)-N-1-{6-[8-(2-morpholin-4-ylethylamino)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}propane-1,3-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400670-63-4
(3-(3-chloro-phenyl)-3-{6-[8-(2-morpholin-4-yl-ethylamino)-imidazo[1,2-a]pyrazin-3-yl]-pyridin-2-ylamino}-propyl)-carbamic acid tert-butyl ester

: 1400670-18-9
1-(3-chlorophenyl)-N-1-{6-[8-(2-morpholin-4-ylethylamino)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}propane-1,3-diamine hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃;

Reference yield:

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 1400670-18-9
1-(3-chlorophenyl)-N-1-{6-[8-(2-morpholin-4-ylethylamino)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}propane-1,3-diamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -10 °C

1.2: 12 h / 20 °C

2.1: N-Bromosuccinimide / 0.5 h / 0 °C

3.1: toluene-4-sulfonic acid / acetonitrile; water / Reflux

4.1: triethylamine / isopropyl alcohol / 16 h / Reflux

5.1: potassium carbonate; DavePhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 130 °C / Inert atmosphere; sealed tube

6.1: hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; N-Bromosuccinimide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; DavePhos; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1400670-18-9
1-(3-chlorophenyl)-N-1-{6-[8-(2-morpholin-4-ylethylamino)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}propane-1,3-diamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / isopropyl alcohol / 16 h / Reflux

2: potassium carbonate; DavePhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 130 °C / Inert atmosphere; sealed tube

3: hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; isopropyl alcohol;