(R)-3-(benzyloxy-formyl-amino)-2-cyclopentylmethyl-N-((S)-1-{4-[(5-methoxy-4-oxo-4H-pyran-2-ylmethyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-propionamide

Base Information

Chemical Name:(R)-3-(benzyloxy-formyl-amino)-2-cyclopentylmethyl-N-((S)-1-{4-[(5-methoxy-4-oxo-4H-pyran-2-ylmethyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-propionamide
CAS No.:1091682-24-4
Molecular Formula:C₃₅H₅₀N₄O₇
Molecular Weight:638.805
Hs Code.:

(R)-3-(benzyloxy-formyl-amino)-2-cyclopentylmethyl-N-((S)-1-{4-[(5-methoxy-4-oxo-4H-pyran-2-ylmethyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-propionamide

Synonyms:(R)-3-(benzyloxy-formyl-amino)-2-cyclopentylmethyl-N-((S)-1-{4-[(5-methoxy-4-oxo-4H-pyran-2-ylmethyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-propionamide

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Chemical Property of (R)-3-(benzyloxy-formyl-amino)-2-cyclopentylmethyl-N-((S)-1-{4-[(5-methoxy-4-oxo-4H-pyran-2-ylmethyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-propionamide

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Technology Process of (R)-3-(benzyloxy-formyl-amino)-2-cyclopentylmethyl-N-((S)-1-{4-[(5-methoxy-4-oxo-4H-pyran-2-ylmethyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-propionamide

There total 8 articles about (R)-3-(benzyloxy-formyl-amino)-2-cyclopentylmethyl-N-((S)-1-{4-[(5-methoxy-4-oxo-4H-pyran-2-ylmethyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: C₄₃H₅₆N₄O₉

: 1091682-24-4
(R)-3-(benzyloxy-formyl-amino)-2-cyclopentylmethyl-N-((S)-1-{4-[(5-methoxy-4-oxo-4H-pyran-2-ylmethyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-propionamide

Guidance literature:: C₄₃H₅₆N₄O₉; With acetic acid; zinc; at 20 ℃; for 17h;

With sodium carbonate; In water; ethyl acetate;

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 1091682-24-4
(R)-3-(benzyloxy-formyl-amino)-2-cyclopentylmethyl-N-((S)-1-{4-[(5-methoxy-4-oxo-4H-pyran-2-ylmethyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-propionamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide / water / 1.33 h / 0 - 20 °C

2.1: thionyl chloride / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 17 h / Heating / reflux

4.1: pyridine / acetonitrile / 1 h / 20 °C

5.1: hydrogenchloride / ethyl acetate

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1.33 h

6.2: 16 h / 20 °C

7.1: hydrogenchloride / ethyl acetate

8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h

8.2: 15 h / 20 °C

9.1: acetic acid; zinc / 17 h / 20 °C

With pyridine; hydrogenchloride; potassium hydroxide; thionyl chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; In water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 6269-25-6
2-Hydroxymethyl-5-methoxy-4H-pyran-4-on

: 1091682-24-4
(R)-3-(benzyloxy-formyl-amino)-2-cyclopentylmethyl-N-((S)-1-{4-[(5-methoxy-4-oxo-4H-pyran-2-ylmethyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-propionamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 17 h / Heating / reflux

3.1: pyridine / acetonitrile / 1 h / 20 °C

4.1: hydrogenchloride / ethyl acetate

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1.33 h

5.2: 16 h / 20 °C

6.1: hydrogenchloride / ethyl acetate

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h

7.2: 15 h / 20 °C

8.1: acetic acid; zinc / 17 h / 20 °C

With pyridine; hydrogenchloride; thionyl chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; In ethyl acetate; N,N-dimethyl-formamide; acetonitrile;