[(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester
CAS No.:1415312-26-3
Molecular Formula:C₁₈H₁₇ClN₂O₃
Molecular Weight:344.798
Hs Code.:

Synonyms:[(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester

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Chemical Property of [(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester

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Technology Process of [(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester

There total 5 articles about [(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 773837-37-9
sodium cyanide

: 1415312-24-1
C₁₇H₁₆ClNO₃

: 1415312-26-3
[(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester

Guidance literature:: C₁₇H₁₆ClNO₃; With sodium hydrogensulfite; In tetrahydrofuran; water; at 0 ℃;

sodium cyanide; In tetrahydrofuran; water;

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 1415312-26-3
[(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / 0 °C

1.2: 4 h / pH 8 - 9

1.3: pH 1

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 °C

4.1: sodium hydrogensulfite / water; tetrahydrofuran / 0 °C

With lithium aluminium tetrahydride; water; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 80126-50-7
(R)-2'-chlorophenylalanine

: 1415312-26-3
[(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / 0 °C

1.2: 4 h / pH 8 - 9

1.3: pH 1

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 °C

4.1: sodium hydrogensulfite / water; tetrahydrofuran / 0 °C

With lithium aluminium tetrahydride; water; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;