Fmoc-NFK

Base Information

• Chemical Name: Fmoc-NFK
• CAS No.: 1290040-15-1
• Molecular Formula: C₂₆H₂₂N₂O₆
• Molecular Weight: 458.47
• Mol file: 1290040-15-1.mol

Synonyms:Fmoc-NFK

Chemical Property of Fmoc-NFK

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fmoc-NFK

There total 7 articles about Fmoc-NFK which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

Fmoc-Trp-OH (35737-15-6) → Fmoc-NFK (1290040-15-1)

Guidance literature:

Fmoc-Trp-OH; With ozone; In dichloromethane; at -78 ℃; for 0.166667h;

With dimethylsulfide; at -78 - 20 ℃; for 2h;

DOI:10.1021/ja4012468

Reference yield:

L-kynurenine (2922-83-0) → Fmoc-NFK (1290040-15-1)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic anhydride / 2 h / 20 °C

2: dichloromethane / 3.5 h / 50 °C

3: dichloromethane / 26 h / 20 °C

4: methanol / 0.5 h / 20 °C

With methanol; acetic anhydride; In dichloromethane;

DOI:10.1002/psc.1322

Reference yield:

(S )-2-Amino-4-(2-formamidophenyl)-4-oxobutanoic acid (3978-11-8) → Fmoc-NFK (1290040-15-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 3.5 h / 50 °C

2: dichloromethane / 26 h / 20 °C

3: methanol / 0.5 h / 20 °C

With methanol; In dichloromethane;

DOI:10.1002/psc.1322

upstream raw materials:

L-kynurenine

(S )-2-Amino-4-(2-formamidophenyl)-4-oxobutanoic acid

L-Tryptophan

2-amino-3-(2-oxoindolin-3-yl)propanoic acid

Downstream raw materials:

Fmoc-L-kynurenine