(S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

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Chemical Name:(S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid
CAS No.:93806-78-1
Molecular Formula:C₃₆H₃₆N₄O₁₄
Molecular Weight:748.7
Hs Code.:

(S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

Synonyms:(S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

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Chemical Property of (S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

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Technology Process of (S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

There total 4 articles about (S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 93806-78-1
(S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH

2: DCC / ethyl acetate; dimethylformamide

3: Et₃N / dimethylformamide; H₂O / 48 h / Ambient temperature

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00381a012

Reference yield:

: 74281-82-6
(2S,3R)-3-hydroxyhomotyrosine

: 93806-78-1
(S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH

2: DCC / ethyl acetate; dimethylformamide

3: Et₃N / dimethylformamide; H₂O / 48 h / Ambient temperature

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00381a012

Reference yield:

: (2S,3R)-N-carbobenzoxy-4'-O-carbobenzoxy-3-hydroxyhomotyrosine

: 93806-78-1
(S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / ethyl acetate; dimethylformamide

2: Et₃N / dimethylformamide; H₂O / 48 h / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00381a012