benzyl-methyl-(4-piperidin-4-yl-butyl)-amine

Base Information

Chemical Name:benzyl-methyl-(4-piperidin-4-yl-butyl)-amine
CAS No.:316363-16-3
Molecular Formula:C₁₇H₂₈N₂
Molecular Weight:260.423
Hs Code.:

Synonyms:benzyl-methyl-(4-piperidin-4-yl-butyl)-amine

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Chemical Property of benzyl-methyl-(4-piperidin-4-yl-butyl)-amine

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Technology Process of benzyl-methyl-(4-piperidin-4-yl-butyl)-amine

There total 10 articles about benzyl-methyl-(4-piperidin-4-yl-butyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 316363-35-6
4-[4-(N-benzoyl-N-methylamino)butyl]piperidine

: 316363-16-3
benzyl-methyl-(4-piperidin-4-yl-butyl)-amine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Heating;
DOI:10.1248/cpb.48.1611

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 316363-16-3
benzyl-methyl-(4-piperidin-4-yl-butyl)-amine

Guidance literature:: Multi-step reaction with 9 steps

1: 63 percent / NaOEt / ethanol / 1.75 h / 5 - 20 °C

2: 97 percent / H₂ / 10 percent Pd/C / ethanol / 8 h / 20 °C

3: 86 percent / NaI; Na₂CO₃ / dimethylformamide / 6 h / 20 °C

4: 96 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

5: Et₃N / tetrahydrofuran / 0.75 h / 0 - 5 °C

6: 98 percent / acetonitrile; H₂O / 15 h / 20 °C

7: 82 percent / 1 N aq. NaOH / acetone / 2 h / 20 °C

8: 91 percent / ammonium formate / 10 percent Pd/C / methanol / 0.5 h / Heating

9: 92 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; sodium ethanolate; ammonium formate; sodium carbonate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetone; acetonitrile; 1: Horner-Emmons reaction;
DOI:10.1248/cpb.48.1611

Reference yield:

: 91370-63-7
ethyl 4-(piperidin-4-yl)butyrate

: 316363-16-3
benzyl-methyl-(4-piperidin-4-yl-butyl)-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / NaI; Na₂CO₃ / dimethylformamide / 6 h / 20 °C

2: 96 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

3: Et₃N / tetrahydrofuran / 0.75 h / 0 - 5 °C

4: 98 percent / acetonitrile; H₂O / 15 h / 20 °C

5: 82 percent / 1 N aq. NaOH / acetone / 2 h / 20 °C

6: 91 percent / ammonium formate / 10 percent Pd/C / methanol / 0.5 h / Heating

7: 92 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; ammonium formate; sodium carbonate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1248/cpb.48.1611