6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride

Base Information

• Chemical Name: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride
• CAS No.: 31127-40-9
• Molecular Formula: C₉H₁₁NO₂*ClH
• Molecular Weight: 201.653
• Mol file: 31127-40-9.mol

Synonyms:(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanamine hydrochloride

Chemical Property of 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1,4-Benzodioxan-6-methylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,4-Benzodioxan-6-methylamine hydrochloride is a reagent that iss used in the preparation of 4-(4-hydroxy-3,5-dimethoxyphenyl)-6,7-dimethoxy-dihydroisoquinolin-3-one.

Technology Process of 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride

There total 4 articles about 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,3-dihydrobenzo[b][1,4]dioxin-6-carbaldoxime (31127-39-6) → (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanamine hydrochloride (31127-40-9)

Guidance literature:

With hydrogenchloride; hydrogen; In water; isopropyl alcohol; at 20 ℃; under 7600.51 Torr; Solvent; Autoclave;

DOI:10.1007/s11172-018-2230-4

Reference yield:

2,3-dihydro-1,4-benzodioxin-6-ylmethylamine (17413-10-4) → (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanamine hydrochloride (31127-40-9)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 25 - 30 ℃; pH=0.25 - 0.75;

Reference yield:

2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde (29668-44-8) → (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanamine hydrochloride (31127-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / 20 °C

2: hydrogenchloride; hydrogen; 5%-palladium/activated carbon / ethanol / 20 °C / 760.05 Torr

With hydrogenchloride; 5%-palladium/activated carbon; hydroxylamine hydrochloride; hydrogen; sodium acetate; In ethanol;

DOI:10.1002/adsc.201300832

upstream raw materials:

2,3-dihydro-1,4-benzodioxin-6-ylmethylamine

2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde

2,3-dihydrobenzo[b][1,4]dioxin-6-carbaldoxime

Downstream raw materials:

(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-[1-(3-iodo-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amine

(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-[1-(3,5-dimethyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine

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