N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride

Base Information

Chemical Name:N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride
CAS No.:737823-67-5
Molecular Formula:C₂₁H₂₃N₅O₃S₂*ClH
Molecular Weight:494.038
Hs Code.:

Synonyms:N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride

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Chemical Property of N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride

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Technology Process of N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride

There total 16 articles about N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 737823-77-7
di-tert-butyl {[(4-{2-[2-(acetylamino)-5-(4-(methylsulfonyl)phenyl)-1,3-thiazol-4-yl]ethyl}phenyl)amino]-methylidene}biscarbamate

: 737823-67-5
N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 13h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 737823-73-3
N-{4-formyl-5-[4-(methylsulfanyl)phenyl]-1,3-thiazol-2-yl}acetamide

: 737823-67-5
N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: Oxone / water; tetrahydrofuran / 0 - 20 °C

3: acetic acid; palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C / 2280.15 Torr

4: tetrahydrofuran / 12 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 13 h / 20 °C / Inert atmosphere

With hydrogenchloride; Oxone; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: N-{5-[4-(methylsulfonyl)phenyl]-4-[2-(4-nitrophenyl)ethenyl]-1,3-thiazol-2-yl}acetamide

: 737823-67-5
N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C / 2280.15 Torr

2: tetrahydrofuran / 12 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 13 h / 20 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1016/j.bmc.2013.02.048