(R)-1-(4-(2-methylpyridin-4-yl)phenyl)-3-(1-(naphthalen-2-yl)ethyl)urea

Base Information

Chemical Name:(R)-1-(4-(2-methylpyridin-4-yl)phenyl)-3-(1-(naphthalen-2-yl)ethyl)urea
CAS No.:1195169-59-5
Molecular Formula:C₂₅H₂₃N₃O
Molecular Weight:381.477
Hs Code.:

Synonyms:(R)-1-(4-(2-methylpyridin-4-yl)phenyl)-3-(1-(naphthalen-2-yl)ethyl)urea

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Chemical Property of (R)-1-(4-(2-methylpyridin-4-yl)phenyl)-3-(1-(naphthalen-2-yl)ethyl)urea

Chemical Property:

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Technology Process of (R)-1-(4-(2-methylpyridin-4-yl)phenyl)-3-(1-(naphthalen-2-yl)ethyl)urea

There total 5 articles about (R)-1-(4-(2-methylpyridin-4-yl)phenyl)-3-(1-(naphthalen-2-yl)ethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1195173-80-8
4-(2-methylpyridin-4-yl)benzoyl azide

: 3082-62-0
(1S)-1-(2-naphthyl)ethylamine

: 1195169-59-5
(R)-1-(4-(2-methylpyridin-4-yl)phenyl)-3-(1-(naphthalen-2-yl)ethyl)urea

Guidance literature:: 4-(2-methylpyridin-4-yl)benzoyl azide; In tetrahydrofuran; at 120 ℃; for 0.25h; microwave irradiation;

(1S)-1-(2-naphthyl)ethylamine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 120 ℃; for 0.25h; microwave irradiation;

Reference yield:

: 22282-99-1
4-bromo-2-methylpyridine

: 1195169-59-5
(R)-1-(4-(2-methylpyridin-4-yl)phenyl)-3-(1-(naphthalen-2-yl)ethyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / dihydrogen dichlorobis(di-tert-butylphosphinito-kP)palladate / 1,2-dimethoxyethane / 4 h / Reflux

2.1: hydrogenchloride; water / 11 h / 100 °C

3.1: triethylamine / tetrahydrofuran / 0.33 h / 0 °C

3.2: 0.5 h / 0 °C

3.3: 2 h / 0 - 20 °C

4.1: tetrahydrofuran / 0.25 h / 120 °C / microwave irradiation

4.2: 0.25 h / 120 °C / microwave irradiation

With hydrogenchloride; water; caesium carbonate; triethylamine; dihydrogen dichlorobis(di-tert-butylphosphinito-kP)palladate; In tetrahydrofuran; 1,2-dimethoxyethane;

Reference yield:

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1195169-59-5
(R)-1-(4-(2-methylpyridin-4-yl)phenyl)-3-(1-(naphthalen-2-yl)ethyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / dihydrogen dichlorobis(di-tert-butylphosphinito-kP)palladate / 1,2-dimethoxyethane / 4 h / Reflux

2.1: hydrogenchloride; water / 11 h / 100 °C

3.1: triethylamine / tetrahydrofuran / 0.33 h / 0 °C

3.2: 0.5 h / 0 °C

3.3: 2 h / 0 - 20 °C

4.1: tetrahydrofuran / 0.25 h / 120 °C / microwave irradiation

4.2: 0.25 h / 120 °C / microwave irradiation

With hydrogenchloride; water; caesium carbonate; triethylamine; dihydrogen dichlorobis(di-tert-butylphosphinito-kP)palladate; In tetrahydrofuran; 1,2-dimethoxyethane;