Sodium 2,2-dichloroacetic acid

Base Information

Chemical Name:Sodium 2,2-dichloroacetic acid
CAS No.:2156-56-1
Molecular Formula:C2HCl2NaO2
Molecular Weight:150.925
Hs Code.:29154000
NSC Number:744479
Mol file:2156-56-1.mol

Synonyms:sodium 2,2-dichloroacetic acid;sodium;2,2-dichloroacetic acid;NSC744479

Suppliers and Price of Sodium 2,2-dichloroacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Sodium dichloroacetate
10g
$ 45.00

TCI Chemical
Sodium Dichloroacetate >99.0%(T)
10g
$ 50.00

TCI Chemical
Sodium Dichloroacetate >99.0%(T)
25g
$ 83.00

TCI Chemical
Sodium Dichloroacetate >97.0%(T)
25g
$ 71.00

Sigma-Aldrich
Sodium dichloroacetate 98%
50g
$ 210.00

Sigma-Aldrich
Sodium dichloroacetate 98%
10g
$ 60.80

CSNpharm
Sodium2,2-dichloroacetate
100mg
$ 47.00

CSNpharm
Sodium2,2-dichloroacetate
250mg
$ 80.00

Crysdot
Sodium2,2-dichloroacetate 97%
100g
$ 146.00

ChemScene
Sodium dichloroacetate >98.0%
100mg
$ 50.00

Total 139 raw suppliers

Chemical Property of Sodium 2,2-dichloroacetic acid

Chemical Property:

Appearance/Colour:white powder
Vapor Pressure:0.196mmHg at 25°C
Melting Point:198 °C (dec.)(lit.)
Boiling Point:194 °C at 760 mmHg
Flash Point:75.6 °C
PSA：40.13000
LogP:-0.46000
Storage Temp.:Desiccate at RT
Sensitive.:Moisture Sensitive
Solubility.:Methanol (Slightly), Water (Slightly)
Water Solubility.:soluble in cold water
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:150.9329540
Heavy Atom Count:7
Complexity:60.6

Purity/Quality:

99% ^*data from raw suppliers

Sodium dichloroacetate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,Xn
Statements: 36/37/38-40
Safety Statements: 26-37/39-36-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C(C(=O)O)(Cl)Cl.[Na+]
Uses Sodium dichloroacetate (DCA) is a mitochondrial pyruvate dehydrogenase kinase inhibitor, and is an orally absorbable small molecular compound for MELAS syndrome, and children with congenital lactic acidosis and other diseases that are treated in the clinic. Recent studies had found that DCA acts as a potential vasoprotective agent by inhibiting PDK2 and reducing coronary endarterium proliferation. Further, DCA promotes brain regeneration after cerebral ischemia, which indicates that DCA might play an important role in VD. Treatment of neurologic injury (pyruvate dehydrogenase activator). Sodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase.

Technology Process of Sodium 2,2-dichloroacetic acid

There total 1 articles about Sodium 2,2-dichloroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 79-43-6
dichloro-acetic acid

: 2156-56-1
sodium dichloroacetate

Guidance literature:: With sodium hydroxide; In water; at 20 ℃; for 2h;
DOI:10.1016/j.jorganchem.2018.05.020

Reference yield: 84.0%

: 72287-26-4,95464-05-4
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride

: 2156-56-1
sodium dichloroacetate

: 494828-95-4
[Pd(O₂CHCl₂)2(1,1'-bis(diphenylphosphino)ferrocene)]

Guidance literature:: With AgNO₃; In dichloromethane; (Ar); mixing palladium complex, sodium and silver salts in CH2Cl2, stirring at room temp. for 16 h in the dark; filtration through celite column, concn., addn. of hexane; elem. anal.;
DOI:10.1016/S0022-328X(02)01645-5