Technology Process of (3aR,4S,5R)-4-iodo-7-methyl-5-phenyl-3,3a,4,5-tetrahydro-1H-oxazolo[3,4-a]quinolin-1-one
There total 5 articles about (3aR,4S,5R)-4-iodo-7-methyl-5-phenyl-3,3a,4,5-tetrahydro-1H-oxazolo[3,4-a]quinolin-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride;
In
acetic acid;
at 20 ℃;
for 1h;
DOI:10.1002/asia.201100453
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1R,2R)-2-(2-hydroxyethoxy)cyclohexyl]thiourea / cyclohexane / 24 h / 20 °C / Molecular sieve; Inert atmosphere
2: lithium triethylborohydride / tetrahydrofuran / -78 - 20 °C
3: toluene / 3 h / 80 °C
4: N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride / acetic acid / 1 h / 20 °C
With
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1R,2R)-2-(2-hydroxyethoxy)cyclohexyl]thiourea; lithium triethylborohydride; N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride;
In
tetrahydrofuran; cyclohexane; acetic acid; toluene;
1: Petasis reaction;
DOI:10.1002/asia.201100453
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium triethylborohydride / tetrahydrofuran / -78 - 20 °C
2: toluene / 3 h / 80 °C
3: N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride / acetic acid / 1 h / 20 °C
With
lithium triethylborohydride; N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride;
In
tetrahydrofuran; acetic acid; toluene;
DOI:10.1002/asia.201100453
