(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

Base Information

• Chemical Name: (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid
• CAS No.: 123993-32-8
• Molecular Formula: C₂₀H₂₉NO₆
• Molecular Weight: 379.453
• Mol file: 123993-32-8.mol

Synonyms:(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

Chemical Property of (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

There total 3 articles about (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid methylester (123993-30-6) → (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid (123993-32-8)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Ambient temperature;

DOI:10.1021/jo00290a021

Reference yield:

(S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester (123993-28-2) → (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid (123993-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / toluene / 4 h / 80 °C

2: 78 percent / NaOH / methanol / 2 h / Ambient temperature

With sodium hydroxide; In methanol; toluene;

DOI:10.1021/jo00290a021

Reference yield:

N,N-dimethylformamide di-tert-butyl acetal (36805-97-7) → (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid (123993-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / toluene / 4 h / 80 °C

2: 78 percent / NaOH / methanol / 2 h / Ambient temperature

With sodium hydroxide; In methanol; toluene;

DOI:10.1021/jo00290a021

upstream raw materials:

(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid methylester

(S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester

N,N-dimethylformamide di-tert-butyl acetal