(S)-N-(1-{4-[3-(4-hydroxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

Base Information

Chemical Name:(S)-N-(1-{4-[3-(4-hydroxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide
CAS No.:1446008-05-4
Molecular Formula:C₁₉H₂₂N₂O₃
Molecular Weight:326.395
Hs Code.:

Synonyms:(S)-N-(1-{4-[3-(4-hydroxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

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Chemical Property of (S)-N-(1-{4-[3-(4-hydroxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

Chemical Property:

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Technology Process of (S)-N-(1-{4-[3-(4-hydroxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

There total 3 articles about (S)-N-(1-{4-[3-(4-hydroxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1446007-25-5
(S)-N-(1-{4-[3-(4-benzyloxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

: 1446008-05-4
(S)-N-(1-{4-[3-(4-hydroxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; for 12h; under 2250.23 Torr;

Reference yield:

: 186296-23-1
(S)-N-(1-(4-bromophenyl)ethyl)acetamide

: 1446008-05-4
(S)-N-(1-{4-[3-(4-hydroxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 48 h / 30 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 °C / 2250.23 Torr

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; johnphos; sodium t-butanolate; In 1,4-dioxane; methanol;

Reference yield:

: 27298-97-1
(S)-1-(4-bromophenyl)ethylamine

: 1446008-05-4
(S)-N-(1-{4-[3-(4-hydroxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 12 h / 20 - 30 °C

2: sodium t-butanolate; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 48 h / 30 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 °C / 2250.23 Torr

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; johnphos; sodium t-butanolate; In 1,4-dioxane; methanol; dichloromethane;