3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:181817-46-9
Molecular Formula:C₁₈H₂₀N₂O₃S
Molecular Weight:344.434
Hs Code.:

Synonyms:3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

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Technology Process of 3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

There total 5 articles about 3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(3-isobutyl-ureido)-5-(4-methoxy-phenyl)-4-methyl-thiophene-3-carboxylic acid ethyl ester

: 181817-46-9
3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 16h;
DOI:10.1021/jm020180i

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 181817-46-9
3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: NH₄OAc; AcOH / toluene / 20 h / Heating

1.2: 40 percent / sulfur / ethanol / 2 h / 65 °C

2.1: toluene / 96 h / Heating

3.1: 1.61 g / NaOMe / methanol / 16 h / 20 °C

With ammonium acetate; sodium methylate; acetic acid; In methanol; toluene;
DOI:10.1021/jm020180i

Reference yield:

: 165809-38-1
2-amino-4-methyl-5-(4-methoxyphenyl)thiophene-3-carboxylic acid ethyl ester

: 181817-46-9
3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 96 h / Heating

2: 1.61 g / NaOMe / methanol / 16 h / 20 °C

With sodium methylate; In methanol; toluene;
DOI:10.1021/jm020180i