2-[1-(2,6-Difluoro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide

Base Information

Chemical Name:2-[1-(2,6-Difluoro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide
CAS No.:610296-31-6
Molecular Formula:C₃₃H₂₉F₃N₂O
Molecular Weight:526.601
Hs Code.:

Synonyms:2-[1-(2,6-Difluoro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide

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Chemical Property of 2-[1-(2,6-Difluoro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide

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Technology Process of 2-[1-(2,6-Difluoro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide

There total 5 articles about 2-[1-(2,6-Difluoro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 610296-39-4
1-(2,6-difluoro-phenyl)-1,2,3,4-tetrahydro-isoquinoline

: 610298-62-9
2-chloro-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide

: 610296-31-6
2-[1-(2,6-Difluoro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 20h;

Reference yield:

: 64248-56-2
1-bromo-2,6-difluorobenzene

: 610296-31-6
2-[1-(2,6-Difluoro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hexane / -78 °C

2.1: tetrahydrofuran / 1 h / 0 °C

2.2: 3 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 19 h / 20 °C / 2585.81 Torr

4.1: potassium carbonate / acetonitrile / 20 h / 80 °C

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; ethyl acetate; acetonitrile;

Reference yield:

: 119-65-3
isoquinoline

: 610296-31-6
2-[1-(2,6-Difluoro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 19 h / 20 °C / 2585.81 Torr

3.1: potassium carbonate / acetonitrile / 20 h / 80 °C

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; acetonitrile;