USP7-IN-1

Base Information

• Chemical Name: USP7-IN-1
• CAS No.: 1381291-36-6
• Molecular Formula: C₂₃H₂₄ClN₃O₃
• Molecular Weight: 425.915
• Mol file: 1381291-36-6.mol

Synonyms:7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}-3,4-dihydroquinazolin-4-one

Chemical Property of USP7-IN-1

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

USP7-IN-1 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of USP7-IN-1

There total 5 articles about USP7-IN-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl 4-[(7-chloro-4-oxo-3,4-dihydroquinazolin-3-yl)methyl]-4-hydroxypiperidine-1-carboxylate (1426340-66-0) + 3-Phenylpropionic acid (501-52-0) → 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}-3,4-dihydroquinazolin-4-one (1381291-36-6)

Guidance literature:

tert-butyl 4-[(7-chloro-4-oxo-3,4-dihydroquinazolin-3-yl)methyl]-4-hydroxypiperidine-1-carboxylate; With trifluoroacetic acid; at 20 ℃; for 4h;

3-Phenylpropionic acid; With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield: 80.0%

7-chloro-3-((4-hydroxypiperidin-4-yl)methyl)quinazolin-4(3H)-one + 3-Phenylpropionic acid (501-52-0) → 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}-3,4-dihydroquinazolin-4-one (1381291-36-6)

Guidance literature:

3-Phenylpropionic acid; With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

7-chloro-3-((4-hydroxypiperidin-4-yl)methyl)quinazolin-4(3H)-one; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2021.113291

Reference yield:

2-Amino-4-chlorobenzoic acid (89-77-0) → 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}-3,4-dihydroquinazolin-4-one (1381291-36-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 12 h / 150 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

3.1: trifluoroacetic acid / 4 h / 20 °C

4.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 5 h / 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2021.113291

upstream raw materials:

tert-butyl 4-[(7-chloro-4-oxo-3,4-dihydroquinazolin-3-yl)methyl]-4-hydroxypiperidine-1-carboxylate

3-Phenylpropionic acid

2-Amino-4-chlorobenzoic acid

7-chloro-3,4-dihydroquinazolin-4-one