(S)-2-(methoxycarbonylamino)-2-(4-(phenylmethoxy)phenyl)succinic acid 1-methyl ester 4-tert-butyl ester

Base Information

Chemical Name:(S)-2-(methoxycarbonylamino)-2-(4-(phenylmethoxy)phenyl)succinic acid 1-methyl ester 4-tert-butyl ester
CAS No.:473930-72-2
Molecular Formula:C₂₄H₂₉NO₇
Molecular Weight:443.497
Hs Code.:

Synonyms:(S)-2-(methoxycarbonylamino)-2-(4-(phenylmethoxy)phenyl)succinic acid 1-methyl ester 4-tert-butyl ester

Suppliers and Price of (S)-2-(methoxycarbonylamino)-2-(4-(phenylmethoxy)phenyl)succinic acid 1-methyl ester 4-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-(methoxycarbonylamino)-2-(4-(phenylmethoxy)phenyl)succinic acid 1-methyl ester 4-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-(methoxycarbonylamino)-2-(4-(phenylmethoxy)phenyl)succinic acid 1-methyl ester 4-tert-butyl ester

There total 5 articles about (S)-2-(methoxycarbonylamino)-2-(4-(phenylmethoxy)phenyl)succinic acid 1-methyl ester 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 473930-71-1
(2S,4S)-4-(4-Benzyloxy-phenyl)-4-tert-butoxycarbonylmethyl-5-oxo-2-phenyl-oxazolidine-3-carboxylic acid methyl ester

: 473930-72-2
(S)-2-(methoxycarbonylamino)-2-(4-(phenylmethoxy)phenyl)succinic acid 1-methyl ester 4-tert-butyl ester

Guidance literature:: With lithium hydroxide; In methanol; at 20 ℃; for 24h;
DOI:10.1016/S0957-4166(02)00224-0

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 473930-72-2
(S)-2-(methoxycarbonylamino)-2-(4-(phenylmethoxy)phenyl)succinic acid 1-methyl ester 4-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / KHMDS / tetrahydrofuran / -78 - 20 °C

2: 95 percent / 4N LiOH / methanol / 24 h / 20 °C

With lithium hydroxide; potassium hexamethylsilazane; In tetrahydrofuran; methanol;
DOI:10.1016/S0957-4166(02)00224-0

Reference yield:

: 336877-72-6
L-2-[p-(benzyloxy)phenyl]glycine

: 473930-72-2
(S)-2-(methoxycarbonylamino)-2-(4-(phenylmethoxy)phenyl)succinic acid 1-methyl ester 4-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaHCO₃ / H₂O; CHCl₃ / 24 h

2: 23.6 g / BF₃*Et₂O / CH₂Cl₂ / 2 h / 0 °C

3: 88 percent / KHMDS / tetrahydrofuran / -78 - 20 °C

4: 95 percent / 4N LiOH / methanol / 24 h / 20 °C

With lithium hydroxide; boron trifluoride diethyl etherate; potassium hexamethylsilazane; sodium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane; chloroform; water;
DOI:10.1016/S0957-4166(02)00224-0