1-(2,4-dimethoxy-phenyl)-3-(4-prop-2-ynyloxy-phenyl)-propenone

Base Information

• Chemical Name: 1-(2,4-dimethoxy-phenyl)-3-(4-prop-2-ynyloxy-phenyl)-propenone
• CAS No.: 1227420-49-6
• Molecular Formula: C₂₀H₁₈O₄
• Molecular Weight: 322.361
• Mol file: 1227420-49-6.mol

Synonyms:1-(2,4-dimethoxy-phenyl)-3-(4-prop-2-ynyloxy-phenyl)-propenone

Chemical Property of 1-(2,4-dimethoxy-phenyl)-3-(4-prop-2-ynyloxy-phenyl)-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(2,4-dimethoxy-phenyl)-3-(4-prop-2-ynyloxy-phenyl)-propenone

There total 1 articles about 1-(2,4-dimethoxy-phenyl)-3-(4-prop-2-ynyloxy-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 1-(2,4-dimethoxy-phenyl)-3-(4-prop-2-ynyloxy-phenyl)-propenone (1227420-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14.83 h / -5 - 30 °C / Inert atmosphere

2: potassium hydroxide; hydrogenchloride / ethanol; water / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; 2: |Claisen-Schmidt Condensation;

DOI:10.1016/j.poly.2016.10.001

Reference yield:

3-azidopropyltriethoxysilane (83315-69-9) + 1-(2,4-dimethoxy-phenyl)-3-(4-prop-2-ynyloxy-phenyl)-propenone (1227420-49-6) → 3-(4-(-(1-(3-(Triethoxysilyl)propyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1-(2,4-dimethoxyphenyl)prop-2-en-1-one

Guidance literature:

With bromotris(triphenylphosphine)copper(I); triethylamine; In tetrahydrofuran; at 65 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.poly.2016.10.001

Reference yield:

1-(2,4-dimethoxy-phenyl)-3-(4-prop-2-ynyloxy-phenyl)-propenone (1227420-49-6) → 3-(4-(-(1-(3-(triethoxysilyl)propyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1-(2,4-dimethoxyphenyl)prop-2-en-1-one

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; bromotris(triphenylphosphine)copper(I) / tetrahydrofuran / 3 h / 65 °C / Inert atmosphere

2: potassium hydroxide / toluene / 6 h / 110 °C / Inert atmosphere

With bromotris(triphenylphosphine)copper(I); triethylamine; potassium hydroxide; In tetrahydrofuran; toluene;

DOI:10.1016/j.poly.2016.10.001

upstream raw materials:

4-hydroxy-benzaldehyde