(S)-1-(2-hydroxy-6-methoxy-4-methylphenyl)-2-(3-isopropyl-1-methylcyclopent-2-enyl)ethanone

Base Information

Chemical Name:(S)-1-(2-hydroxy-6-methoxy-4-methylphenyl)-2-(3-isopropyl-1-methylcyclopent-2-enyl)ethanone
CAS No.:616206-17-8
Molecular Formula:C₁₉H₂₆O₃
Molecular Weight:302.414
Hs Code.:

Synonyms:(S)-1-(2-hydroxy-6-methoxy-4-methylphenyl)-2-(3-isopropyl-1-methylcyclopent-2-enyl)ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(2-hydroxy-6-methoxy-4-methylphenyl)-2-(3-isopropyl-1-methylcyclopent-2-enyl)ethanone

Chemical Property:

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Technology Process of (S)-1-(2-hydroxy-6-methoxy-4-methylphenyl)-2-(3-isopropyl-1-methylcyclopent-2-enyl)ethanone

There total 11 articles about (S)-1-(2-hydroxy-6-methoxy-4-methylphenyl)-2-(3-isopropyl-1-methylcyclopent-2-enyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 685901-98-8
(S)-trifluoromethanesulfonic acid 5-[2-(2-hydroxy-6-methoxy-4-methylphenyl)-2-oxoethyl]-2-isopropyl-5-methylcyclopent-1-enyl ester

: 616206-17-8
(S)-1-(2-hydroxy-6-methoxy-4-methylphenyl)-2-(3-isopropyl-1-methylcyclopent-2-enyl)ethanone

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; formic acid; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 1h;
DOI:10.1021/ja0497025

Reference yield:

: 504-15-4
orcinol

: 616206-17-8
(S)-1-(2-hydroxy-6-methoxy-4-methylphenyl)-2-(3-isopropyl-1-methylcyclopent-2-enyl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 92 percent / potassium carbonate / acetone / 24 h / Heating

2.1: n-butyllithium / 1,2-dimethoxy-ethane; hexane / 2.5 h / -78 - 20 °C

2.2: 1,2-dimethoxy-ethane; hexane / -78 - -55 °C

3.1: NaHCO₃; Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

4.1: boron trichloride / CH₂Cl₂; hexane / 2 h / -20 °C

5.1: palladium(II) acetate; dppf; formic acid / triethylamine / dimethylformamide / 1 h / 70 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; formic acid; palladium diacetate; boron trichloride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triethylamine; In 1,2-dimethoxyethane; hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja0497025

Reference yield:

: 4179-19-5
1,3-dimethoxy-5-methylbenzene

: 616206-17-8
(S)-1-(2-hydroxy-6-methoxy-4-methylphenyl)-2-(3-isopropyl-1-methylcyclopent-2-enyl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / 1,2-dimethoxy-ethane; hexane / 2.5 h / -78 - 20 °C

1.2: 1,2-dimethoxy-ethane; hexane / -78 - -55 °C

2.1: NaHCO₃; Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

3.1: boron trichloride / CH₂Cl₂; hexane / 2 h / -20 °C

4.1: palladium(II) acetate; dppf; formic acid / triethylamine / dimethylformamide / 1 h / 70 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; formic acid; palladium diacetate; boron trichloride; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; In 1,2-dimethoxyethane; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0497025