(1S,2R,3S)-3-<(tert-Butoxycarbonyl)amino>-3-(2-furyl)-1-(p-methoxyphenyl)-2-methyl-1-propanol

Base Information

Chemical Name:(1S,2R,3S)-3-<(tert-Butoxycarbonyl)amino>-3-(2-furyl)-1-(p-methoxyphenyl)-2-methyl-1-propanol
CAS No.:150823-44-2
Molecular Formula:C₂₀H₂₇NO₅
Molecular Weight:361.438
Hs Code.:

Synonyms:(1S,2R,3S)-3-<(tert-Butoxycarbonyl)amino>-3-(2-furyl)-1-(p-methoxyphenyl)-2-methyl-1-propanol

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Chemical Property of (1S,2R,3S)-3-<(tert-Butoxycarbonyl)amino>-3-(2-furyl)-1-(p-methoxyphenyl)-2-methyl-1-propanol

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Technology Process of (1S,2R,3S)-3-<(tert-Butoxycarbonyl)amino>-3-(2-furyl)-1-(p-methoxyphenyl)-2-methyl-1-propanol

There total 10 articles about (1S,2R,3S)-3-<(tert-Butoxycarbonyl)amino>-3-(2-furyl)-1-(p-methoxyphenyl)-2-methyl-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 150823-41-9
(1S,2R,3S)-3-Amino-3-(2-furyl)-1-(p-methoxyphenyl)-2-methyl-1-propanol

: 150823-44-2
(1S,2R,3S)-3-<(tert-Butoxycarbonyl)amino>-3-(2-furyl)-1-(p-methoxyphenyl)-2-methyl-1-propanol

Guidance literature:: With sodium hydroxide; In water; tert-butyl alcohol;
DOI:10.1021/jo00074a024

Reference yield:

: 617-90-3
2-furancarbonitrile

: 150823-44-2
(1S,2R,3S)-3-<(tert-Butoxycarbonyl)amino>-3-(2-furyl)-1-(p-methoxyphenyl)-2-methyl-1-propanol

Guidance literature:: Multi-step reaction with 8 steps

2: 72 percent / 60 °C

3: 97 percent / NaBH₄ / methanol / Ambient temperature

4: 2 N H₂SO₄ / 1 h / 40 °C

5: NaOH / H₂O; 2-methyl-propan-2-ol

6: TFA / CH₂Cl₂ / 1 h / Ambient temperature

7: N-Selectride / tetrahydrofuran / Ambient temperature

8: NaOH / H₂O; 2-methyl-propan-2-ol

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; sodium tri-sec-butylborohydride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo00074a024

Reference yield:

: 150716-67-9
2-(2-Furyl)-4-(p-methoxyphenyl)-3-methyl-4-(p-tolylamino)-1-aza-1,3-butadiene

: 150823-44-2
(1S,2R,3S)-3-<(tert-Butoxycarbonyl)amino>-3-(2-furyl)-1-(p-methoxyphenyl)-2-methyl-1-propanol

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / 60 °C

2: 97 percent / NaBH₄ / methanol / Ambient temperature

3: 2 N H₂SO₄ / 1 h / 40 °C

4: NaOH / H₂O; 2-methyl-propan-2-ol

5: TFA / CH₂Cl₂ / 1 h / Ambient temperature

6: N-Selectride / tetrahydrofuran / Ambient temperature

7: NaOH / H₂O; 2-methyl-propan-2-ol

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; sodium tri-sec-butylborohydride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo00074a024