((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-2,5-dihydro-pyrrole-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Base Information

Chemical Name:((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-2,5-dihydro-pyrrole-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester
CAS No.:1352392-93-8
Molecular Formula:C₂₁H₂₅BrN₄O₃
Molecular Weight:461.358
Hs Code.:

Synonyms:((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-2,5-dihydro-pyrrole-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Chemical Property of ((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-2,5-dihydro-pyrrole-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Technology Process of ((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-2,5-dihydro-pyrrole-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

There total 11 articles about ((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-2,5-dihydro-pyrrole-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1476720-64-5
4-(4-bromo-phenyl)-2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-imidazole

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1352392-93-8
((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-2,5-dihydro-pyrrole-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1352392-93-8
((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-2,5-dihydro-pyrrole-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; sodium hydroxide / water / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

With sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In dichloromethane; water;

Reference yield:

: 1499-56-5,775275-31-5,790644-51-8,754962-86-2
(R)-4-hydroxy-L-proline ethyl ester

: 1352392-93-8
((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-2,5-dihydro-pyrrole-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2.1: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

5.1: lithium hydroxide; water / tetrahydrofuran / 20 °C / Inert atmosphere

6.1: diethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

7.1: ammonium acetate / toluene / Inert atmosphere; Reflux

8.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hexamethyldisilazane; ammonium acetate; water; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; pyridinium chlorochromate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; acetonitrile;