N-((5-(4-fluoro-2-(2-[18F]fluoromethoxy)phenyl)pyridin-3-yl)methyl)cyclopentanamine

Base Information

Chemical Name:N-((5-(4-fluoro-2-(2-[18F]fluoromethoxy)phenyl)pyridin-3-yl)methyl)cyclopentanamine
CAS No.:1531601-31-6
Molecular Formula:C₁₈H₂₀F₂N₂O
Molecular Weight:317.368
Hs Code.:

Synonyms:N-((5-(4-fluoro-2-(2-[18F]fluoromethoxy)phenyl)pyridin-3-yl)methyl)cyclopentanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((5-(4-fluoro-2-(2-[18F]fluoromethoxy)phenyl)pyridin-3-yl)methyl)cyclopentanamine

Chemical Property:

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Technology Process of N-((5-(4-fluoro-2-(2-[18F]fluoromethoxy)phenyl)pyridin-3-yl)methyl)cyclopentanamine

There total 4 articles about N-((5-(4-fluoro-2-(2-[18F]fluoromethoxy)phenyl)pyridin-3-yl)methyl)cyclopentanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1531601-39-4
2-(5-((cyclopentylamino)methyl)pyridin-3-yl)-5-fluorophenol

: 104839-79-4
[18F]fluoromethyl bromide

: 1531601-31-6
N-((5-(4-fluoro-2-(2-[18F]fluoromethoxy)phenyl)pyridin-3-yl)methyl)cyclopentanamine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 0.25h;

Reference yield:

: 1313192-39-0
N-((5-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine

: 1531601-31-6
N-((5-(4-fluoro-2-(2-[18F]fluoromethoxy)phenyl)pyridin-3-yl)methyl)cyclopentanamine

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 16 h / -78 °C

2: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 100 °C

With boron tribromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1003-03-8
Cyclopentamine

: 1531601-31-6
N-((5-(4-fluoro-2-(2-[18F]fluoromethoxy)phenyl)pyridin-3-yl)methyl)cyclopentanamine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Cooling with ice

2: boron tribromide / dichloromethane / 16 h / -78 °C

3: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 100 °C

With boron tribromide; sodium tris(acetoxy)borohydride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;