N,N-Diethyl-6,7-dihydro-2',5'-dioxo-N-(phenylmethyl)-1'-spirothiophen-4(5H),3'-pyrrolidin>-propanaminiumchlorid

Base Information

• Chemical Name: N,N-Diethyl-6,7-dihydro-2',5'-dioxo-N-(phenylmethyl)-1'-spirothiophen-4(5H),3'-pyrrolidin>-propanaminiumchlorid
• CAS No.: 89434-62-8
• Molecular Formula: C₂₅H₃₃N₂O₂S*Cl
• Molecular Weight: 461.068

Synonyms:N,N-Diethyl-6,7-dihydro-2',5'-dioxo-N-(phenylmethyl)-1'-spirothiophen-4(5H),3'-pyrrolidin>-propanaminiumchlorid

Chemical Property of N,N-Diethyl-6,7-dihydro-2',5'-dioxo-N-(phenylmethyl)-1'-spirothiophen-4(5H),3'-pyrrolidin>-propanaminiumchlorid

Chemical Property:

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Technology Process of N,N-Diethyl-6,7-dihydro-2',5'-dioxo-N-(phenylmethyl)-1'-spirothiophen-4(5H),3'-pyrrolidin>-propanaminiumchlorid

There total 6 articles about N,N-Diethyl-6,7-dihydro-2',5'-dioxo-N-(phenylmethyl)-1'-spirothiophen-4(5H),3'-pyrrolidin>-propanaminiumchlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

benzyl chloride (100-44-7) + 6,7-Dihydro-1'-(3-(N,N-diethylamino)-propyl)-spirothiophen-4(5H),3'-pyrrolidin>-2',5'-dion (89434-55-9) → N,N-Diethyl-6,7-dihydro-2',5'-dioxo-N-(phenylmethyl)-1'-spirothiophen-4(5H),3'-pyrrolidin>-propanaminiumchlorid (89434-62-8)

Guidance literature:

In nitromethane; at 50 ℃; for 7h;

DOI:10.1002/ardp.19843170214

Reference yield:

4-keto-4,5,6,7-tetrahydrothianaphthene (13414-95-4) → N,N-Diethyl-6,7-dihydro-2',5'-dioxo-N-(phenylmethyl)-1'-spirothiophen-4(5H),3'-pyrrolidin>-propanaminiumchlorid (89434-62-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 94 percent / ammonium acetate / acetic acid; benzene / 15 h / Heating

2: 86 percent / aq. ethanol / 0.58 h

3: 91 percent / conc. HCl / acetic acid / 120 h / Heating

4: 70 percent / various solvent(s) / 4 h / Heating

5: 65 percent / 1.) 160 deg C, 1 h, 2.) 2 h. heating, vacuum

6: 91 percent / nitromethane / 7 h / 50 °C

With ammonium acetate; hydrogenchloride; In nitromethane; ethanol; acetic acid; benzene;

DOI:10.1002/ardp.19843170214

Reference yield:

6,7-Dihydro-benzothiophen-4(5H)-yliden-propandinitril (89434-49-1) → N,N-Diethyl-6,7-dihydro-2',5'-dioxo-N-(phenylmethyl)-1'-spirothiophen-4(5H),3'-pyrrolidin>-propanaminiumchlorid (89434-62-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 86 percent / aq. ethanol / 0.58 h

2: 91 percent / conc. HCl / acetic acid / 120 h / Heating

3: 70 percent / various solvent(s) / 4 h / Heating

4: 65 percent / 1.) 160 deg C, 1 h, 2.) 2 h. heating, vacuum

5: 91 percent / nitromethane / 7 h / 50 °C

With hydrogenchloride; In nitromethane; ethanol; acetic acid;

DOI:10.1002/ardp.19843170214

upstream raw materials:

benzyl chloride

6,7-Dihydro-1'-(3-(N,N-diethylamino)-propyl)-spirothiophen-4(5H),3'-pyrrolidin>-2',5'-dion

4-keto-4,5,6,7-tetrahydrothianaphthene

6,7-Dihydro-benzothiophen-4(5H)-yliden-propandinitril

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