<3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-pentanoate

Base Information

Chemical Name:<3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-pentanoate
CAS No.:110972-06-0
Molecular Formula:C₃₀H₄₆O₄Si
Molecular Weight:498.778
Hs Code.:

<3aS-<3aα,4α(1E,3R<sup>*</sup>),5β,6aα>>-methyl 5-<hexahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-(dimethylphenylsilyl)-2(1H)-pentalenylidene>pentanoate

Synonyms:<3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-pentanoate

Suppliers and Price of <3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-pentanoate

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Technology Process of <3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-pentanoate

There total 8 articles about <3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 110972-05-9
<3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-oxy>-4-<3-<<(1,1-dimethylathyl)dimethylsilyl>oxy>-1-octenyl>-1-(dimethylphenylsilyl)-2(1H)-pentalenylidene>pentanoate

: 110972-06-0
<3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-pentanoate

Guidance literature:: With perchloric acid; In methanol; diethyl ether; at 18 ℃; for 0.5h;
DOI:10.1021/jo00234a014

Reference yield:

: 59895-16-8
5,6-Didehydro-11,15-O-bis(tert-butyldimethylsilyl)PGE₂ methyl ester

: 110972-06-0
<3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / Zn, TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

2: 1.) methyl acetate, 9-borabicyclo<3.3.1>nonane, 2.) NaOH, 30percent H₂O₂ / 1.) THF, 0 deg C, 2.5 h, 2.) THF, 0 deg C, 30 min

3: 85 percent / pyridinium dichromate / CH₂Cl₂ / 11 h / 20 °C

4: 85 percent / tetrahydrofuran / 0.5 h / -78 °C

5: 90 percent / 4-(dimethylamino)pyridine / acetonitrile / 15 h / 18 °C

6: 75 percent / Mg(ClO₄)2, N-methylcarbazole / tetrahydrofuran; H₂O / 16 h / 18 °C / Irradiation

7: 98 percent / aq. perchloric acid / diethyl ether; methanol / 0.5 h / 18 °C

With dmap; sodium hydroxide; dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; perchloric acid; magnesium(II) perchlorate; N-methylcarbazole; acetic acid methyl ester; dihydrogen peroxide; titanium tetrachloride; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00234a014

Reference yield:

: 110972-00-4
(9α,11α,13E,15S)-methyl 11,15-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-9-(hydroxymethyl)prost-13-en-5-yn-1-oate

: 110972-06-0
<3aS-<3aα,4α(1E,3R^*),5β,6aα>>-methyl 5-pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / pyridinium dichromate / CH₂Cl₂ / 11 h / 20 °C

2: 85 percent / tetrahydrofuran / 0.5 h / -78 °C

3: 90 percent / 4-(dimethylamino)pyridine / acetonitrile / 15 h / 18 °C

4: 75 percent / Mg(ClO₄)2, N-methylcarbazole / tetrahydrofuran; H₂O / 16 h / 18 °C / Irradiation

5: 98 percent / aq. perchloric acid / diethyl ether; methanol / 0.5 h / 18 °C

With dmap; dipyridinium dichromate; perchloric acid; magnesium(II) perchlorate; N-methylcarbazole; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00234a014