2',3'-O,N-((4-methoxy)benzylidene-7-(1,2-O-isopropylidene-malyl) paclitaxel

Base Information

Chemical Name:2',3'-O,N-((4-methoxy)benzylidene-7-(1,2-O-isopropylidene-malyl) paclitaxel
CAS No.:265659-43-6
Molecular Formula:C₆₂H₆₅NO₁₉
Molecular Weight:1128.19
Hs Code.:

Synonyms:2',3'-O,N-((4-methoxy)benzylidene-7-(1,2-O-isopropylidene-malyl) paclitaxel

Suppliers and Price of 2',3'-O,N-((4-methoxy)benzylidene-7-(1,2-O-isopropylidene-malyl) paclitaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2',3'-O,N-((4-methoxy)benzylidene-7-(1,2-O-isopropylidene-malyl) paclitaxel

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Technology Process of 2',3'-O,N-((4-methoxy)benzylidene-7-(1,2-O-isopropylidene-malyl) paclitaxel

There total 2 articles about 2',3'-O,N-((4-methoxy)benzylidene-7-(1,2-O-isopropylidene-malyl) paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 949023-16-9
(4S,5R)-3-benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

: 265659-42-5
7-(1,2-O-isopropylidene-malyl) baccatin III

: 265659-43-6
2',3'-O,N-((4-methoxy)benzylidene-7-(1,2-O-isopropylidene-malyl) paclitaxel

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1016/S0968-0896(99)00301-6

Reference yield:

: 27548-93-2
baccatin III

: 265659-43-6
2',3'-O,N-((4-methoxy)benzylidene-7-(1,2-O-isopropylidene-malyl) paclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / DCC; DMAP / CH₂Cl₂ / 24 h / 20 °C

2: 74 percent / DCC; DMAP / CH₂Cl₂ / 8 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; 1: Esterification / 2: Esterification;
DOI:10.1016/S0968-0896(99)00301-6