2-((2,4-dimethyl-2-(((3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)methyl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetic acid

Base Information

Chemical Name:2-((2,4-dimethyl-2-(((3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)methyl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetic acid
CAS No.:1353880-89-3
Molecular Formula:C₂₆H₂₅FN₆O₅
Molecular Weight:520.52
Hs Code.:

Synonyms:2-((2,4-dimethyl-2-(((3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)methyl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetic acid

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Chemical Property of 2-((2,4-dimethyl-2-(((3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)methyl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetic acid

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Technology Process of 2-((2,4-dimethyl-2-(((3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)methyl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetic acid

There total 8 articles about 2-((2,4-dimethyl-2-(((3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)methyl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1353880-83-7
ethyl 2-((2,4-dimethyl-2-(((3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)methyl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetate

: 1353880-89-3
2-((2,4-dimethyl-2-(((3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)methyl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield:

: C₂₄H₂₃FN₆O₂

: 1353880-89-3
2-((2,4-dimethyl-2-(((3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)methyl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 20 °C

3: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

With sodium tetrahydroborate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1056737-05-3
(2,4-dimethyl-7-nitro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methanol

: 1353880-89-3
2-((2,4-dimethyl-2-(((3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)methyl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 20 - 110 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 18751.9 Torr

3.1: methanol / 12 h / 20 °C / Molecular sieve; Inert atmosphere

4.1: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 20 °C

6.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;