benzyl 1-phenyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

Base Information

Chemical Name:benzyl 1-phenyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate
CAS No.:1356928-25-0
Molecular Formula:C₂₅H₂₅N₃O₂
Molecular Weight:399.492
Hs Code.:

Synonyms:benzyl 1-phenyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

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Chemical Property of benzyl 1-phenyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

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Technology Process of benzyl 1-phenyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

There total 3 articles about benzyl 1-phenyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1301214-81-2
8-(dimethylaminomethylene)-9-oxo-3-azaspiro[5.5]undec-10-ene-3-carboxylic acid benzyl ester

: 59-88-1
phenylhydrazine hydrochloride

: 1356928-25-0
benzyl 1-phenyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

Guidance literature:: With acetic acid; In ethanol; at 90 ℃; for 18h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo202377g

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1356928-25-0
benzyl 1-phenyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / benzene / 24 h / 70 - 110 °C / Inert atmosphere

2: toluene / 5 h / 110 °C / Inert atmosphere

3: acetic acid / ethanol / 18 h / 90 °C / Inert atmosphere

With toluene-4-sulfonic acid; acetic acid; In ethanol; toluene; benzene; 1: Robinson annulation;
DOI:10.1021/jo202377g

Reference yield:

: 189333-18-4
3-oxo-9-azaspiro[5.5]undec-4-ene-9-carboxylic acid benzyl ester

: 1356928-25-0
benzyl 1-phenyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 5 h / 110 °C / Inert atmosphere

2: acetic acid / ethanol / 18 h / 90 °C / Inert atmosphere

With acetic acid; In ethanol; toluene;
DOI:10.1021/jo202377g