1-(2-hydroxyethyl)-5-{2-[5-(4-methylpiperazin-1-yl)-2-trifluoromethoxyphenylamino]pyrimidin-4-yl}-1H-pyrrole-3-carboxylic acid amide

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Chemical Name:1-(2-hydroxyethyl)-5-{2-[5-(4-methylpiperazin-1-yl)-2-trifluoromethoxyphenylamino]pyrimidin-4-yl}-1H-pyrrole-3-carboxylic acid amide
CAS No.:1137468-02-0
Molecular Formula:C₂₃H₂₆F₃N₇O₃
Molecular Weight:505.5
Hs Code.:

Synonyms:1-(2-hydroxyethyl)-5-{2-[5-(4-methylpiperazin-1-yl)-2-trifluoromethoxyphenylamino]pyrimidin-4-yl}-1H-pyrrole-3-carboxylic acid amide

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Chemical Property of 1-(2-hydroxyethyl)-5-{2-[5-(4-methylpiperazin-1-yl)-2-trifluoromethoxyphenylamino]pyrimidin-4-yl}-1H-pyrrole-3-carboxylic acid amide

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Technology Process of 1-(2-hydroxyethyl)-5-{2-[5-(4-methylpiperazin-1-yl)-2-trifluoromethoxyphenylamino]pyrimidin-4-yl}-1H-pyrrole-3-carboxylic acid amide

There total 6 articles about 1-(2-hydroxyethyl)-5-{2-[5-(4-methylpiperazin-1-yl)-2-trifluoromethoxyphenylamino]pyrimidin-4-yl}-1H-pyrrole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1137467-83-4
5-{2-[5-(4-methylpiperazin-1-yl)-2-trifluoromethoxyphenylamino]pyrimidin-4-yl}-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrrole-3-carboxylic acid amide

: 1137468-02-0
1-(2-hydroxyethyl)-5-{2-[5-(4-methylpiperazin-1-yl)-2-trifluoromethoxyphenylamino]pyrimidin-4-yl}-1H-pyrrole-3-carboxylic acid amide

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2011.11.065

Reference yield:

: 1137468-07-5
5-(2-amino-pyrimidin-4-yl)-1H-pyrrole-3-carboxylic acid ethyl ester

: 1137468-02-0
1-(2-hydroxyethyl)-5-{2-[5-(4-methylpiperazin-1-yl)-2-trifluoromethoxyphenylamino]pyrimidin-4-yl}-1H-pyrrole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran; dimethyl sulfoxide / 12 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 8 h / 110 °C

3: potassium hydroxide / ethanol / 3 h / 80 °C

4: N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C

5: toluene-4-sulfonic acid / methanol / 6 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-hydroxybenzotriazole ammonium salt; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.11.065

Reference yield:

: 1137468-12-2
5-(2-aminopyrimidin-4-yl)-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrrole-3-carboxylic acid ethyl ester

: 1137468-02-0
1-(2-hydroxyethyl)-5-{2-[5-(4-methylpiperazin-1-yl)-2-trifluoromethoxyphenylamino]pyrimidin-4-yl}-1H-pyrrole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 8 h / 110 °C

2: potassium hydroxide / ethanol / 3 h / 80 °C

3: N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C

4: toluene-4-sulfonic acid / methanol / 6 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-hydroxybenzotriazole ammonium salt; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; potassium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.11.065