ethyl 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-((3-fluorophenyl)amino)benzoate

Base Information

Chemical Name:ethyl 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-((3-fluorophenyl)amino)benzoate
CAS No.:1445878-84-1
Molecular Formula:C₃₃H₃₁FN₆O₆S
Molecular Weight:658.71
Hs Code.:

Synonyms:ethyl 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-((3-fluorophenyl)amino)benzoate

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Chemical Property of ethyl 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-((3-fluorophenyl)amino)benzoate

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Technology Process of ethyl 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-((3-fluorophenyl)amino)benzoate

There total 6 articles about ethyl 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-((3-fluorophenyl)amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445879-89-9
7-bromo-4-chloro-N-cyclopropyl-3-quinolinesulfonamide

: 1445878-84-1
ethyl 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-((3-fluorophenyl)amino)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C

2: acetic acid

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; In 1,4-dioxane; water;

Reference yield:

: 1445879-81-1
7-bromo-4-hydroxy-3-quinolinesulfonyl chloride

: 1445878-84-1
ethyl 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-((3-fluorophenyl)amino)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / Reflux

2: triethylamine / dichloromethane / 1 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C

4: acetic acid

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 690260-94-7
ethyl 3-bromo-5-nitrobenzoate

: 1445878-84-1
ethyl 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-((3-fluorophenyl)amino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; palladium diacetate; XPhos / tert-butyl alcohol; toluene / 0.33 h / 120 °C / Microwave irradiation

2: acetic acid; palladium 10% on activated carbon; hydrogen / 2 h / 20 °C

3: acetic acid

With palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; acetic acid; XPhos; In toluene; tert-butyl alcohol;