((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

Base Information

Chemical Name:((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester
CAS No.:1196992-44-5
Molecular Formula:C₄₉H₅₂N₄O₇S
Molecular Weight:841.04
Hs Code.:

((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

Synonyms:((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

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Chemical Property of ((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

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Technology Process of ((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

There total 1 articles about ((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: {(R)-2-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(tritylsulfanyl)propionylamino]-3-methylbutyrylamino}-acetic acid methyl ester

: 94744-50-0
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid

: 1196992-44-5
((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

Guidance literature:: {(R)-2-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(tritylsulfanyl)propionylamino]-3-methylbutyrylamino}-acetic acid methyl ester; With diethylamine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 51.0%

: 1196992-44-5
((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

: 180973-24-4
(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

: 1196992-46-7
((R)-2-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

Guidance literature:: ((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester; With diethylamine; In acetonitrile; at 20 ℃; for 1.25h; Inert atmosphere;

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1196992-44-5
((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

: 1196992-48-9
(6R,9S,16S)-6-isopropyl-12,12-dimethyl-16-((E)-4-tritylsulfanyl-but-1-enyl)-9-tritylsulfanylmethyl-1-oxa-4,7,10,13-tetraaza-cyclohexadecane-2,5,8,11,14-pentaone

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylamine / acetonitrile / 1.25 h / 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: water; lithium hydroxide / dichloromethane; tetrahydrofuran / 0.75 h / 0 °C

2.3: 20 °C / Inert atmosphere

With water; diethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;