2-(4-methoxyphenyl)-5-phenylthiophene

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-5-phenylthiophene
• CAS No.: 59086-11-2
• Molecular Formula: C₁₇H₁₄OS
• Molecular Weight: 266.364
• Mol file: 59086-11-2.mol

Synonyms:2-(4-methoxyphenyl)-5-phenylthiophene

Chemical Property of 2-(4-methoxyphenyl)-5-phenylthiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4-methoxyphenyl)-5-phenylthiophene

There total 23 articles about 2-(4-methoxyphenyl)-5-phenylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-bromo-4-methoxy-benzene (104-92-7) + triethyl(5-phenylthiophen-2-yl)silane → 2-(4-methoxyphenyl)-5-phenylthiophene (59086-11-2)

Guidance literature:

With copper (II)-fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris(2,4,6-trimethoxyphenyl)phosphine; cesium fluoride; at 100 ℃; for 17h; Inert atmosphere; Glovebox;

DOI:10.1002/anie.201712081

Reference yield: 89.0%

2-phenylthiophene (825-55-8) + 4-chloromethoxybenzene (623-12-1) → 2-(4-methoxyphenyl)-5-phenylthiophene (59086-11-2)

Guidance literature:

With NHC-Pd(II)-Im; potassium tert-butylate; copper(II) oxide; In tetrahydrofuran; at 130 ℃; for 3h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2016.11.053

Reference yield: 88.0%

(E,E)-1-(4-methoxyphenyl)-4-phenyl-1,3-butadiene (22145-08-0) → 2-(4-methoxyphenyl)-5-phenylthiophene (59086-11-2)

Guidance literature:

With potassium disulfide; dimethyl sulfoxide; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 24h; Schlenk technique;

DOI:10.1021/acs.orglett.8b03078

upstream raw materials:

1-(4-methoxyphenyl)-4-phenyl-1,4-butanedione

[(Z)-1-(4-Methoxy-phenyl)-3-oxo-propenylsulfanyl]-phenyl-acetic acid methyl ester

(Z,Z)-1,4-di(benzylthio)-1-(p-methoxyphenyl)-4-phenyl-1,3-butadiene

2-phenylthiophene

Downstream raw materials:

4-(5-phenyl-2-thienyl)phenol

Refernces

• 1、 Paix?o, Douglas B.,Rampon, Daniel S.,Salles, Helena D.,Soares, Eduardo G. O.,Bilheri, Filipe N.,Schneider, Paulo H.. "Trithiocarbonate Anion as a Sulfur Source for the Synthesis of 2,5-Disubstituted Thiophenes and 2-Substituted Benzo[ b]thiophenes". supporting information. p. 12922 - 12934. Retrieved 2020/11/26.
• 2、 Chen, Liang,Min, Hao,Zeng, Weilan,Zhu, Xiaoming,Liang, Yun,Deng, Guobo,Yang, Yuan. "Transition-Metal-Free Sulfuration/Annulation of Alkenes: Economical Access to Thiophenes Enabled by the Cleavage of Multiple C-H Bonds". supporting information. p. 7392 - 7395. Retrieved 2019/01/03.