3-[(phosphonic acid diethyl ester)-methyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

Base Information

Chemical Name:3-[(phosphonic acid diethyl ester)-methyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide
CAS No.:1282521-37-2
Molecular Formula:C₁₉H₂₇N₂O₅PS
Molecular Weight:426.474
Hs Code.:

Synonyms:3-[(phosphonic acid diethyl ester)-methyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

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Chemical Property of 3-[(phosphonic acid diethyl ester)-methyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

Chemical Property:

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Technology Process of 3-[(phosphonic acid diethyl ester)-methyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

There total 6 articles about 3-[(phosphonic acid diethyl ester)-methyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.7%

: 1282520-87-9
3-bromomethyl-5-isobutoxy-N-(thiazol-2-yl)-benzamide

: 122-52-1
triethyl phosphite

: 1282521-37-2
3-[(phosphonic acid diethyl ester)-methyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

Guidance literature:: at 160 ℃; for 3h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282521-37-2
3-[(phosphonic acid diethyl ester)-methyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 40 °C

2: potassium hydroxide; methanol / tetrahydrofuran / 10 h / 100 °C

3: dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

4: lithium borohydride; ethanol / tetrahydrofuran / 48 h / 0 - 20 °C

5: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

6: 3 h / 160 °C

With methanol; lithium borohydride; ethanol; tribromide phosphate; potassium carbonate; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1185753-91-6
dimethyl 5-(isobutyloxy)isophthalate

: 1282521-37-2
3-[(phosphonic acid diethyl ester)-methyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide; methanol / tetrahydrofuran / 10 h / 100 °C

2: dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

3: lithium borohydride; ethanol / tetrahydrofuran / 48 h / 0 - 20 °C

4: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5: 3 h / 160 °C

With methanol; lithium borohydride; ethanol; tribromo phosphate; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; dichloromethane;