(R)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

Base Information

Chemical Name:(R)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol
CAS No.:1255340-44-3
Molecular Formula:C₂₆H₃₂F₃N₇O₃
Molecular Weight:547.58
Hs Code.:

Synonyms:(R)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

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Chemical Property of (R)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

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Technology Process of (R)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

There total 4 articles about (R)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13889-98-0
N-acetylpiperidine

: 1255342-27-8
1-(4-{4-hydroxy-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenoxy)propan-2-one

: 1255340-46-5
(S)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

: 1255340-44-3
(R)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

Guidance literature:: N-acetylpiperidine; 1-(4-{4-hydroxy-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenoxy)propan-2-one; With acetic acid; magnesium sulfate; In tetrahydrofuran; at 20 ℃; for 4h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; for 16h;

Reference yield:

: 40971-95-7
6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

: 1255340-46-5
(S)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

: 1255340-44-3
(R)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C

2.1: potassium carbonate / N,N-dimethyl acetamide / 2 h / 100 °C

3.1: acetic acid / magnesium sulfate / tetrahydrofuran / 4 h / 20 °C

3.2: 16 h

With potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; magnesium sulfate; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1166820-36-5
4-(4-hydroxyphenyl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

: 1255340-46-5
(S)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

: 1255340-44-3
(R)-4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl acetamide / 2 h / 100 °C

2.1: acetic acid / magnesium sulfate / tetrahydrofuran / 4 h / 20 °C

2.2: 16 h

With potassium carbonate; acetic acid; magnesium sulfate; In tetrahydrofuran; N,N-dimethyl acetamide;