Chemical Property of Nefazodone hydrochloride
Chemical Property:
- Appearance/Colour:white solid
- Vapor Pressure:2.46E-14mmHg at 25°C
- Melting Point:186-188 °C
- Boiling Point:599.6 °C at 760 mmHg
- Flash Point:316.4 °C
- PSA：55.53000
- LogP:4.35680
- Storage Temp.:Desiccate at RT
- Solubility.:DMSO: ~11 mg/mL at 60 °C
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:10
- Exact Mass:505.2011307
- Heavy Atom Count:34
- Complexity:649
- Purity/Quality:
-
99%, *data from raw suppliers
Nefazodone hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl
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Description
Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT2 receptor antagonist
and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to
enhance 5-HTIA-mediated neurotransmission. Distinct from the first generation
agents such as tricyclic antidepressants, nefazodone has very selective
serotonergic effects with negligible affinity for cholinergic and histamine receptors,
and low affinity for a1 -adrenergic receptors. Therefore, it has a superior toxicity
profile that does not produce agitation, insomnia, and lacks cardiac side effects.
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Uses
An antidepressant acts by modifying serotonin transmission. Mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.
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Therapeutic Function
Antidepressant
