1-(2-{4-[(2S,3S)-7-Methoxymethoxy-2-(4-methoxymethoxy-phenyl)-thiochroman-3-yl]-phenoxy}-ethyl)-piperidine

Base Information

Chemical Name:1-(2-{4-[(2S,3S)-7-Methoxymethoxy-2-(4-methoxymethoxy-phenyl)-thiochroman-3-yl]-phenoxy}-ethyl)-piperidine
CAS No.:879713-44-7
Molecular Formula:C₃₂H₃₉NO₅S
Molecular Weight:549.731
Hs Code.:

Synonyms:1-(2-{4-[(2S,3S)-7-Methoxymethoxy-2-(4-methoxymethoxy-phenyl)-thiochroman-3-yl]-phenoxy}-ethyl)-piperidine

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Chemical Property of 1-(2-{4-[(2S,3S)-7-Methoxymethoxy-2-(4-methoxymethoxy-phenyl)-thiochroman-3-yl]-phenoxy}-ethyl)-piperidine

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Technology Process of 1-(2-{4-[(2S,3S)-7-Methoxymethoxy-2-(4-methoxymethoxy-phenyl)-thiochroman-3-yl]-phenoxy}-ethyl)-piperidine

There total 10 articles about 1-(2-{4-[(2S,3S)-7-Methoxymethoxy-2-(4-methoxymethoxy-phenyl)-thiochroman-3-yl]-phenoxy}-ethyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 879713-37-8
4-benzyloxy-2-tert-butylsulfanyl-benzaldehyde

: 879713-44-7
1-(2-{4-[(2S,3S)-7-Methoxymethoxy-2-(4-methoxymethoxy-phenyl)-thiochroman-3-yl]-phenoxy}-ethyl)-piperidine

Guidance literature:: Multi-step reaction with 8 steps

1: 50 percent / piperidine; AcOH / 48 h / 110 °C

2: LiAlH₄ / tetrahydrofuran / 0 °C

3: TFA / CH₂Cl₂ / 0.17 h / -5 °C

4: 75 percent / H₂ / Pd black / ethanol / 48 h / 20 °C

5: Chiracel AD HPLC column / hexane; propan-2-ol

6: NaH / dimethylformamide / 20 °C

7: TBAF; HOAc / tetrahydrofuran

8: Cs₂CO₃ / acetone / Heating

With piperidine; lithium aluminium tetrahydride; Chiracel AD HPLC column; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; caesium carbonate; acetic acid; trifluoroacetic acid; palladium; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; 1: Knoevenagel reaction;
DOI:10.3987/COM-05-S(T)7

Reference yield:

: 412051-40-2
4'-methoxymethyloxy-2-(4-Triisopropylsilyloxy-phenyl)acetophenone

: 879713-44-7
1-(2-{4-[(2S,3S)-7-Methoxymethoxy-2-(4-methoxymethoxy-phenyl)-thiochroman-3-yl]-phenoxy}-ethyl)-piperidine

Guidance literature:: Multi-step reaction with 8 steps

1: 50 percent / piperidine; AcOH / 48 h / 110 °C

2: LiAlH₄ / tetrahydrofuran / 0 °C

3: TFA / CH₂Cl₂ / 0.17 h / -5 °C

4: 75 percent / H₂ / Pd black / ethanol / 48 h / 20 °C

5: Chiracel AD HPLC column / hexane; propan-2-ol

6: NaH / dimethylformamide / 20 °C

7: TBAF; HOAc / tetrahydrofuran

8: Cs₂CO₃ / acetone / Heating

With piperidine; lithium aluminium tetrahydride; Chiracel AD HPLC column; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; caesium carbonate; acetic acid; trifluoroacetic acid; palladium; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; 1: Knoevenagel reaction;
DOI:10.3987/COM-05-S(T)7

Reference yield:

: {4-[7-benzyloxy-2-(4-methoxymethoxy-phenyl)-2H-thiochromen-3-yl]-phenoxy}-triisopropyl-silane

: 879713-44-7
1-(2-{4-[(2S,3S)-7-Methoxymethoxy-2-(4-methoxymethoxy-phenyl)-thiochroman-3-yl]-phenoxy}-ethyl)-piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / H₂ / Pd black / ethanol / 48 h / 20 °C

2: Chiracel AD HPLC column / hexane; propan-2-ol

3: NaH / dimethylformamide / 20 °C

4: TBAF; HOAc / tetrahydrofuran

5: Cs₂CO₃ / acetone / Heating

With Chiracel AD HPLC column; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; caesium carbonate; acetic acid; palladium; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; isopropyl alcohol; acetone;
DOI:10.3987/COM-05-S(T)7