2-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl dihydrogen phosphate

Base Information

Chemical Name:2-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl dihydrogen phosphate
CAS No.:1403881-35-5
Molecular Formula:C₁₉H₁₃BrF₅N₂O₇P
Molecular Weight:587.191
Hs Code.:

Synonyms:2-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl dihydrogen phosphate

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Chemical Property of 2-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl dihydrogen phosphate

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Technology Process of 2-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl dihydrogen phosphate

There total 10 articles about 2-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: diallyl 2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl phosphate

: 1403881-35-5
2-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl dihydrogen phosphate

Guidance literature:: With tri-n-butyl-tin hydride; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403881-35-5
2-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 10 steps

1: 2 h / 130 °C

2: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

3: triethylamine / dichloromethane / 20 °C / Cooling with ice

4: N-Bromosuccinimide; acetic acid / 20 °C

5: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

6: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

7: potassium carbonate / methanol / 1 h / 20 °C

8: 1H-tetrazole / dichloromethane / 16 h / 20 °C

9: tert.-butylhydroperoxide / dichloromethane / 16 h / 0 °C

10: tri-n-butyl-tin hydride / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 2 h / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; potassium carbonate; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1403883-97-5
2-(4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl acetate

: 1403881-35-5
2-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide; acetic acid / 20 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4: potassium carbonate / methanol / 1 h / 20 °C

5: 1H-tetrazole / dichloromethane / 16 h / 20 °C

6: tert.-butylhydroperoxide / dichloromethane / 16 h / 0 °C

7: tri-n-butyl-tin hydride / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 2 h / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; potassium carbonate; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;