benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester

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Chemical Name:benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester
CAS No.:633305-58-5
Molecular Formula:C₆₁H₈₇NO₉Si₃
Molecular Weight:1062.62
Hs Code.:

benzoic acid 1-{4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-6-[2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(<i>tert</i>-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester

Synonyms:benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester

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Chemical Property of benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester

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Technology Process of benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester

There total 7 articles about benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-7-(tert-butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-3-oxo-heptyl ester

: 633305-58-5
benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester

: benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester

Guidance literature:: With titanium tetrachloride; at 20 ℃;
DOI:10.1055/s-2003-41462

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 633305-58-5
benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 87 percent / BF₃*Et₂O / CH₂Cl₂; hexane / 0.5 h / 0 °C

2.1: 86 percent / aq. CuCl; oxygen / PdCl₂ / dimethylformamide / 12 h / 20 °C

3.1: LiHMDS / tetrahydrofuran / -78 °C

4.1: TiCl₄ / tetrahydrofuran / 0.5 h / -78 °C

4.2: 334 mg / tetrahydrofuran / 2 h / -78 °C

5.1: DMAP; pyridine / 3 h / 20 °C

6.1: 411 mg / 4 Angstroem molecular sieves; TiCl₄ / tetrahydrofuran / 3.25 h / 0 - 20 °C

With pyridine; dmap; 4 A molecular sieve; boron trifluoride diethyl etherate; oxygen; titanium tetrachloride; copper(l) chloride; lithium hexamethyldisilazane; palladium dichloride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 2.1: Wacker oxidation;
DOI:10.1002/chem.200500892

Reference yield:

: 633305-66-5
(R)-tert-butyl-(3-(4-methoxybenzyloxy)hex-5-enyloxy)-diphenylsilane

: 633305-58-5
benzoic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 86 percent / aq. CuCl; oxygen / PdCl₂ / dimethylformamide / 12 h / 20 °C

2.1: LiHMDS / tetrahydrofuran / -78 °C

3.1: TiCl₄ / tetrahydrofuran / 0.5 h / -78 °C

3.2: 334 mg / tetrahydrofuran / 2 h / -78 °C

4.1: DMAP; pyridine / 3 h / 20 °C

5.1: 411 mg / 4 Angstroem molecular sieves; TiCl₄ / tetrahydrofuran / 3.25 h / 0 - 20 °C

With pyridine; dmap; 4 A molecular sieve; oxygen; titanium tetrachloride; copper(l) chloride; lithium hexamethyldisilazane; palladium dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Wacker oxidation;
DOI:10.1002/chem.200500892