((S)-1-{(S)-2-[5-(4-Chloro-3-cyano-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Base Information

Chemical Name:((S)-1-{(S)-2-[5-(4-Chloro-3-cyano-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester
CAS No.:1399845-04-5
Molecular Formula:C₂₁H₂₄ClN₅O₃
Molecular Weight:429.906
Hs Code.:

Synonyms:((S)-1-{(S)-2-[5-(4-Chloro-3-cyano-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Chemical Property of ((S)-1-{(S)-2-[5-(4-Chloro-3-cyano-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Technology Process of ((S)-1-{(S)-2-[5-(4-Chloro-3-cyano-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

There total 8 articles about ((S)-1-{(S)-2-[5-(4-Chloro-3-cyano-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 871332-95-5
(4-chloro-3-cyanophenyl)boronic acid

: 1303533-83-6
methyl {(S)-1-[(2S)-2-(5-iodo-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate

: 1399845-04-5
((S)-1-{(S)-2-[5-(4-Chloro-3-cyano-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; tert-butyl alcohol; at 90 ℃; for 4h; Sealed tube; Inert atmosphere;

Reference yield:

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1399845-04-5
((S)-1-{(S)-2-[5-(4-Chloro-3-cyano-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tert-butyl alcohol / 4 h / 90 °C / Sealed tube; Inert atmosphere

With sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1399845-04-5
((S)-1-{(S)-2-[5-(4-Chloro-3-cyano-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Glyoxal; ammonium hydroxide / dichloromethane; water; methanol / 20 °C

2: N-iodo-succinimide / dichloromethane / 1 h / 0 °C

3: sodium sulfite / ethanol; water / 24 h / 110 °C

4: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

6: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tert-butyl alcohol / 4 h / 90 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; ammonium hydroxide; N-iodo-succinimide; Glyoxal; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium sulfite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;