(2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine

Base Information

Chemical Name:(2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine
CAS No.:1374023-37-6
Molecular Formula:C₁₉H₂₅NO
Molecular Weight:283.414
Hs Code.:

Synonyms:(2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine

Suppliers and Price of (2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine

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Technology Process of (2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine

There total 1 articles about (2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2579-22-8
Phenylpropargyl aldehyde

: 55179-51-6
(-)-aminomenthol

: 1374023-37-6
(2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine

Guidance literature:: In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/ejoc.201101462

Reference yield: 80.0%

: 1374023-37-6
(2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine

: 106-95-6
allyl bromide

: (4aS,7R,8aR)-N-allyl-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine

Guidance literature:: In acetonitrile; for 72h; Reflux;
DOI:10.1002/ejoc.201101462

Reference yield:

: 15226-74-1,61091-28-9,61117-58-6
dicobalt octacarbonyl

: 498-66-8
norbornene

: 1374023-37-6
(2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine

: 1407504-88-4
C₂₇H₃₅NO₂

: 1407504-90-8
C₂₇H₃₅NO₂

: C₂₇H₃₅NO₂

Guidance literature:: dicobalt octacarbonyl; norbornene; (2S,4aS,7R,8aR)-2-[2-phenylacetylenyl]-4,4,7-trimethyloctahydrobenz[e][1,3]oxazine; In dichloromethane; at 25 ℃; for 2h; Molecular sieve; Inert atmosphere;

With trimethylamine-N-oxide; In dichloromethane; at 25 ℃; for 3h; Overall yield = 90 %; diastereoselective reaction;
DOI:10.1016/j.tet.2012.08.006