bis(1-methylethyl) (4R)-trans-2-methyl-2-(2-oxocyclohexyl)-1,3-dioxolan-4,5-dicarboxylate

Base Information

Chemical Name:bis(1-methylethyl) (4R)-trans-2-methyl-2-(2-oxocyclohexyl)-1,3-dioxolan-4,5-dicarboxylate
CAS No.:140631-16-9
Molecular Formula:C₁₈H₂₈O₇
Molecular Weight:356.416
Hs Code.:

Synonyms:bis(1-methylethyl) (4R)-trans-2-methyl-2-(2-oxocyclohexyl)-1,3-dioxolan-4,5-dicarboxylate

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Chemical Property of bis(1-methylethyl) (4R)-trans-2-methyl-2-(2-oxocyclohexyl)-1,3-dioxolan-4,5-dicarboxylate

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Technology Process of bis(1-methylethyl) (4R)-trans-2-methyl-2-(2-oxocyclohexyl)-1,3-dioxolan-4,5-dicarboxylate

There total 3 articles about bis(1-methylethyl) (4R)-trans-2-methyl-2-(2-oxocyclohexyl)-1,3-dioxolan-4,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6651-36-1
1-(Trimethylsilyloxy)cyclohexene

: 130258-01-4
diisopropyl (4R,5R)-2-ethoxy-2-methyl-1,3-dioxolan-4,5-dicarboxylate

: 140631-16-9
bis(1-methylethyl) (4R)-trans-2-methyl-2-(2-oxocyclohexyl)-1,3-dioxolan-4,5-dicarboxylate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -60 ℃; for 3h;
DOI:10.1039/c39900000759

Reference yield:

: 6651-36-1
1-(Trimethylsilyloxy)cyclohexene

: 140430-21-3
bis(1-methylethyl) (4R)-trans-2-methyl-2-methoxy-1,3-dioxolan-4,5-dicarboxylate

: 140631-16-9
bis(1-methylethyl) (4R)-trans-2-methyl-2-(2-oxocyclohexyl)-1,3-dioxolan-4,5-dicarboxylate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -60 ℃; for 4h;
DOI:10.1016/S0040-4020(01)90792-6

Reference yield:

: 2217-15-4
L-(+)-diisopropyl tartrate

: 140631-16-9
bis(1-methylethyl) (4R)-trans-2-methyl-2-(2-oxocyclohexyl)-1,3-dioxolan-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / conc. H₂SO₄ / benzene / 80 °C

2: 80 percent Chromat_. / BF₃*Et₂O / CH₂Cl₂ / 4 h / -60 °C

With sulfuric acid; boron trifluoride diethyl etherate; In dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)90792-6