Pamidronate disodium salt

Base Information

• Chemical Name: Pamidronate disodium salt
• CAS No.: 57248-88-1
• Molecular Formula: C3H9NNa2O7P2
• Molecular Weight: 279.03
• Hs Code.: 29319090
• European Community (EC) Number: 260-647-1
• NCI Thesaurus Code: C1345
• RXCUI: 105443
• Mol file: 57248-88-1.mol

Synonyms:Phosphonicacid, (3-amino-1-hydroxypropylidene)bis-, disodium salt (9CI);3-Amino-1-hydroxypropane-1,1-diphosphonicacid disodium salt;APD;Aminomux;Aredia;CGP 23339A;CGP 23339AE;Disodium3-amino-1-hydroxypropane-1,1-diphosphonate;Pamidronic acid disodium salt;

Chemical Property of Pamidronate disodium salt

Chemical Property:

• Appearance/Colour: White Crystals
• Vapor Pressure: 3.79E-20mmHg at 25°C
• Melting Point: 300 °C
• Boiling Point: 658.7 °C at 760 mmHg
• Flash Point: 352.2 °C
• PSA: 186.59000
• LogP: -0.08660
• Storage Temp.: 2-8°C
• Solubility.: H2O: 28 mg/mL
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 278.96496419
• Heavy Atom Count: 15
• Complexity: 263

Purity/Quality:

99% ^*data from raw suppliers

Pamidronic acid, sodium salt hydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-48-41-37/38-20/21/22
• Safety Statements: 22-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
• Recent ClinicalTrials: Combination Chemo, Peripheral Stem Cell Transplant, Biological Therapy, Pamidronate and Thalidomide for Multiple Myeloma
• Recent EU Clinical Trials: The effect of pamidronate treatment on bone health in patients with neuromuscular disease undergoing hip surgery.
• Description: Disodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.
• Uses: Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis. A farnesyl diphosphate synthase inhibitor