Amifostine

Base Information Edit

Chemical Name:Amifostine
CAS No.:20537-88-6
Deprecated CAS:53028-04-9
Molecular Formula:C5H15N2O3PS
Molecular Weight:214.225
Hs Code.:2930909090
European Community (EC) Number:633-786-4
NSC Number:758236,296961
UNII:ILA426L95O
DSSTox Substance ID:DTXSID8022585
Nikkaji Number:J23.675F
Wikipedia:Amifostine
Wikidata:Q251698
NCI Thesaurus Code:C66724
RXCUI:1545987
Metabolomics Workbench ID:43365
ChEMBL ID:CHEMBL1006
Mol file:20537-88-6.mol

Synonyms:Amifostine;Amifostine Anhydrous;Amifostine Disodium Salt;Amifostine Monohydrate;Amifostine Monohydrochloride;Amifostine Trihydrate;Aminopropyl Aminoethylthiophosphate;Aminopropylaminoethylthiophosphate;Aminopropylaminoethylthiophosphoric Acid;APAETP;Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihydrate;Ethiofos;Ethiofos Anhydrous;Ethyol;Gammaphos;NSC 296961;NSC-296961;NSC296961;S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid;WR 2721;WR-2721;WR2721;YM 08310;YM-08310;YM08310

Suppliers and Price of Amifostine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Amifostine
100mg
$ 55.00

Tocris
Amifostine
100
$ 102.00

Sigma-Aldrich
Amifostine United States Pharmacopeia (USP) Reference Standard
150 mg
$ 366.00

Medical Isotopes, Inc.
Amifostine
50 mg
$ 2000.00

ChemScene
Amifostine ≥98.0%
10mg
$ 65.00

ChemScene
Amifostine ≥98.0%
50mg
$ 272.00

AvaChem
Amifostine
100mg
$ 129.00

AvaChem
Amifostine
5g
$ 790.00

AvaChem
Amifostine
1g
$ 259.00

AK Scientific
Amifostine
5mg
$ 34.00

Total 132 raw suppliers

Chemical Property of Amifostine Edit

Chemical Property:

Appearance/Colour:White solid
Melting Point:160.161 °C
Boiling Point:441.7 °C at 760 mmHg
PKA:1.28±0.10(Predicted)
Flash Point:220.9 °C
PSA：130.69000
Density:1.367 g/cm³
LogP:0.84190
Storage Temp.:2-8°C
Solubility.:Soluble in Water.
XLogP3:-4.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:214.05410052
Heavy Atom Count:12
Complexity:152

Purity/Quality:

99%, ^*data from raw suppliers

Amifostine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xn,Xi
Statements: 22-36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(CN)CNCCSP(=O)(O)O
Recent ClinicalTrials:Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer
Recent EU Clinical Trials:Phase II parallel studies on the use of 3D-radiotherapy plus Amifostine or IMRT to evaluate xerostomia reduction in patients with head and neck cancer treated in definitve or postoperative setting.
Description Amifostine, an organic thiophosphate, was introduced for the reduction of cisplatin-induced renal toxicity in patients with advanced ovarian cancer. It is also a radio-protective agent. Amifostine is a prodrug which is rapidly dephosphorylated, preferentially in non-tumor tissues to the active thiol. This agent binds to chemotherapeutic drugs and free radicals released by radiotherapy. The protective effect of amifostine was observed in a wide range of normal organs including bone marrow and gastrointestinal mucosa without interfering with the anti-tumor effect of chemohadiotherapy, indicating an increased therapeutic index for existing cancer treatment. Amifostine is also being evaluated as a cytoprotective in other types of tumors including lung, breast, head and neck cancers. It was reported to be a potent mucolytic with potential in cystic fibrosis.
Uses It is a thiophosphate derivative of cysteamine; provides normal cells with selective protection against the toxic effects of cancer chemotherapy and radiation treatment
Therapeutic Function Radioprotective, Chemoprotectant, Mucolytic

Technology Process of Amifostine

There total 7 articles about Amifostine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

: 23545-42-8
dibromohydrate du N-(bromoethyl-2)diamino-1,3 propane

: 20537-88-6
amifostine

Guidance literature:: With sulfolane; benzyltriethylammonium bromide; sodium hydroxide; phosphorus trichloride; In water; at 25 ℃; for 2h; Reagent/catalyst;