Technology Process of 6-oxo-N-<carbonyl>-L-norleucine phenylmethyl ester
There total 11 articles about 6-oxo-N-<carbonyl>-L-norleucine phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / TsOH*H2O / CHCl3 / Heating
2: 95 percent / Al, HgCl2 / tetrahydrofuran / 4 h / -78 °C
3: 95 percent / LiOH / Ambient temperature
4: 46 percent / 1-hydroxybenzotriazole, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / CH2Cl2; dimethylformamide / 12 h / Ambient temperature
5: 1.) 9-BBN, 2.) PCC, 4 Angstroems MS / 1.) THF, 0 deg C to rt, 1 h, 2.) THF, CH2Cl2, reflux, 1.5 h
With
lithium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; 4 Angstroems MS; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; aluminium; mercury dichloride;
In
tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo9822941
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / Al, HgCl2 / tetrahydrofuran / 4 h / -78 °C
2: 95 percent / LiOH / Ambient temperature
3: 46 percent / 1-hydroxybenzotriazole, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / CH2Cl2; dimethylformamide / 12 h / Ambient temperature
4: 1.) 9-BBN, 2.) PCC, 4 Angstroems MS / 1.) THF, 0 deg C to rt, 1 h, 2.) THF, CH2Cl2, reflux, 1.5 h
With
lithium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; 4 Angstroems MS; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; aluminium; mercury dichloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo9822941
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / LiOH / Ambient temperature
2: 46 percent / 1-hydroxybenzotriazole, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / CH2Cl2; dimethylformamide / 12 h / Ambient temperature
3: 1.) 9-BBN, 2.) PCC, 4 Angstroems MS / 1.) THF, 0 deg C to rt, 1 h, 2.) THF, CH2Cl2, reflux, 1.5 h
With
lithium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; 4 Angstroems MS; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo9822941
